Journal article
Influence of time and number of antigen encounters on memory CD8 T cell development
Immunologic research, Vol.59(1), pp.35-44
08/2014
DOI: 10.1007/s12026-014-8522-3
PMID: 24825776
Abstract
CD8 T cells are an important part of the adaptive immune system providing protection against intracellular bacteria, viruses, and protozoa. After infection and/or vaccination, increased numbers of antigen-specific CD8 T cells remain as a memory population that is capable of responding and providing enhanced protection during reinfection. Experimental studies indicate that while memory CD8 T cells can be maintained for great lengths of time, their properties change with time after infection and/or vaccination. However, the full scope of these changes and what effects they have on memory CD8 T cell function remain unknown. In addition, memory CD8 T cells can encounter antigen multiple times through either reinfection or prime-boost vaccine strategies designed to increase numbers of protective memory CD8 T cells. Importantly, recent studies suggest that memory CD8 T cell development following infection and/or vaccination is influenced by the number of times they have encountered cognate antigen. Since protection offered by memory CD8 T cells in response to infection depends on both the numbers and quality (functional characteristics) at the time of pathogen re-encounter, a thorough understanding of how time and antigen stimulation history impacts memory CD8 T cell properties is critical for the design of vaccines aimed at establishing populations of long-lived, protective memory CD8 T cells.
Details
- Title: Subtitle
- Influence of time and number of antigen encounters on memory CD8 T cell development
- Creators
- Matthew Martin - Interdisciplinary Graduate Program in Immunology University of Iowa Iowa City IA 52242 USAVladimir Badovinac - Interdisciplinary Graduate Program in Immunology University of Iowa Iowa City IA 52242 USA
- Contributors
- Gail A Bishop (Editor)
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.59(1), pp.35-44
- DOI
- 10.1007/s12026-014-8522-3
- PMID
- 24825776
- NLM abbreviation
- Immunol Res
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Publisher
- Springer US; New York
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Microbiology and Immunology; President; Pathology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984047650502771
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