Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine

Christopher E Lopez; Kevin L Legge

doi:10.3390/vaccines8030434

Back

Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine

Journal article

Open access

Peer reviewed

Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine

Christopher E Lopez and Kevin L Legge

Vaccines (Basel), Vol.8(3), pp.1-23

09/01/2020

DOI: 10.3390/vaccines8030434

PMID: 32756443

Files and links (1)

url

https://doi.org/10.3390/vaccines8030434View

Published (Version of record) Open Access

Abstract

Influenza virus infections represent a serious public health threat and account for significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. Despite being an important countermeasure to combat influenza virus and being highly efficacious when matched to circulating influenza viruses, current preventative strategies of vaccination against influenza virus often provide incomplete protection due the continuous antigenic drift/shift of circulating strains of influenza virus. Prevention and control of influenza virus infection with vaccines is dependent on the host immune response induced by vaccination and the various vaccine platforms induce different components of the local and systemic immune response. This review focuses on the immune basis of current (inactivated influenza vaccines (IIV) and live attenuated influenza vaccines (LAIV)) as well as novel vaccine platforms against influenza virus. Particular emphasis will be placed on how each platform induces cross-protection against heterologous influenza viruses, as well as how this immunity compares to and contrasts from the “gold standard” of immunity generated by natural influenza virus infection.

adaptive immunity

antibody

influenza virus

Review

T cells

vaccine

Details

Title: Subtitle: Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine
Creators: Christopher E Lopez - University of Iowa
Kevin L Legge - University of Iowa
Resource Type: Journal article
Publication Details: Vaccines (Basel), Vol.8(3), pp.1-23
DOI: 10.3390/vaccines8030434
PMID: 32756443
NLM abbreviation: Vaccines (Basel)
ISSN: 2076-393X
eISSN: 2076-393X
Publisher: MDPI
Grant note: DOI: 10.13039/100000009, name: National Institutes of Health, award: R01AI127565, R01AI141196
Language: English
Date published: 09/01/2020
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984186488202771

Metrics

4 Record Views

30 Times Cited - Web of Science