Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells

Matthew M Hufford; Graham Richardson; Haixia Zhou; Balaji Manicassamy; Adolfo García-Sastre; Richard I Enelow; Thomas J Braciale

doi:10.1371/journal.pone.0046581

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Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells

Journal article

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Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells

Matthew M Hufford, Graham Richardson, Haixia Zhou, Balaji Manicassamy, Adolfo García-Sastre, Richard I Enelow and Thomas J Braciale

PloS one, Vol.7(10), pp.e46581-e46581

2012

DOI: 10.1371/journal.pone.0046581

PMCID: PMC3466305

PMID: 23056353

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Abstract

Influenza A virus (IAV) is a leading cause of respiratory tract disease worldwide. Anti-viral CD8(+) T lymphocytes responding to IAV infection are believed to eliminate virally infected cells by direct cytolysis but may also contribute to pulmonary inflammation and tissue damage via the release of pro-inflammatory mediators following recognition of viral antigen displaying cells. We have previously demonstrated that IAV antigen expressing inflammatory cells of hematopoietic origin within the infected lung interstitium serve as antigen presenting cells (APC) for infiltrating effector CD8(+) T lymphocytes; however, the spectrum of inflammatory cell types capable of serving as APC was not determined. Here, we demonstrate that viral antigen displaying neutrophils infiltrating the IAV infected lungs are an important cell type capable of acting as APC for effector CD8(+) T lymphocytes in the infected lungs and that neutrophils expressing viral antigen as a result of direct infection by IAV exhibit the most potent APC activity. Our findings suggest that in addition to their suggested role in induction of the innate immune responses to IAV, virus clearance, and the development of pulmonary injury, neutrophils can serve as APCs to anti-viral effector CD8(+) T cells within the infected lung interstitium.

Antigen-Presenting Cells - immunology

CD8-Positive T-Lymphocytes - immunology

Humans

Lung - immunology

Lung - virology

Neutrophils - immunology

Neutrophils - virology

Orthomyxoviridae - immunology

Details

Title: Subtitle: Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells
Creators: Matthew M Hufford - Beirne B. Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
Graham Richardson
Haixia Zhou
Balaji Manicassamy - University of Iowa, Microbiology and Immunology
Adolfo García-Sastre - Icahn School of Medicine at Mount Sinai
Richard I Enelow
Thomas J Braciale
Resource Type: Journal article
Publication Details: PloS one, Vol.7(10), pp.e46581-e46581
DOI: 10.1371/journal.pone.0046581
PMID: 23056353
PMCID: PMC3466305
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Grant note: U-10 AI-83024 / NIAID NIH HHS T32 AI007496-13 / NIAID NIH HHS R01 AI-37293 / NIAID NIH HHS R01 AI037293 / NIAID NIH HHS K99 AI095320 / NIAID NIH HHS R01 AI-15608 / NIAID NIH HHS U01 AI095611 / NIAID NIH HHS R01 HL-33391 / NHLBI NIH HHS R01 AI015608 / NIAID NIH HHS U01 AI-095611 / NIAID NIH HHS R01 HL033391 / NHLBI NIH HHS 1K99 AI095320-01 / NIAID NIH HHS U19 AI-083025 / NIAID NIH HHS U19 AI083025 / NIAID NIH HHS U-19 AI-83024 / NIAID NIH HHS U19 AI083024 / NIAID NIH HHS T32 AI055432 / NIAID NIH HHS T32 AI007496 / NIAID NIH HHS
Language: English
Date published: 2012
Academic Unit: Microbiology and Immunology
Record Identifier: 9984210057302771

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