Journal article
Influenza vaccination during pregnancy and risk of selected major structural non-cardiac birth defects, National Birth Defects Prevention Study 2006-2011
Pharmacoepidemiology and drug safety, Vol.31(8), pp.851-862
04/02/2022
DOI: 10.1002/pds.5435
PMCID: PMC10331487
PMID: 35366035
Abstract
To assess associations between influenza vaccination during etiologically-relevant windows and selected major structural non-cardiac birth defects.
We analyzed data from the National Birth Defects Prevention Study, a multisite, population-based case-control study, for 8233 case children diagnosed with a birth defect and 4937 control children without a birth defect with delivery dates during 2006-2011. For all analyses except for neural tube defects (NTDs), we classified mothers who reported influenza vaccination one month before through the third pregnancy month as exposed; the exposure window for NTDs was one month before through the first pregnancy month. For defects with five or more exposed case children, we used logistic regression to estimate propensity score-adjusted odds ratios (aORs) and 95% confidence intervals (CIs), adjusting for estimated delivery year and season; maternal age; race/ethnicity; plurality; smoking and alcohol use; low folate intake; and, for NTDs, folate antagonist medications.
There were 334 (4.1%) case and 197 (4.0%) control mothers who reported influenza vaccination from one month before through the third pregnancy month. Adjusted ORs ranged from 0.53 for omphalocele to 1.74 for duodenal atresia/stenosis. Most aORs (11 of 19) were ≤1 and all adjusted CIs included the null. The unadjusted CIs for two defects, hypospadias and craniosynostosis, excluded the null. These estimates were attenuated upon covariate adjustment (hypospadias aOR: 1.25 (95% CI 0.89, 1.76); craniosynostosis aOR: 1.23 (95% CI: 0.88, 1.74)).
Results for several non-cardiac major birth defects add to the existing evidence supporting the safety of inactivated influenza vaccination during pregnancy. Under-reporting of vaccination may have biased estimates downward. This article is protected by copyright. All rights reserved.
Details
- Title: Subtitle
- Influenza vaccination during pregnancy and risk of selected major structural non-cardiac birth defects, National Birth Defects Prevention Study 2006-2011
- Creators
- Kristin Palmsten - HealthPartnersJonathan Suhl - University of IowaKristin M Conway - University of IowaElyse O Kharbanda - HealthPartnersElizabeth C Ailes - National Center on Birth Defects and Developmental DisabilitiesJanet D Cragan - Metropolitan Atlanta Congenital Defects Program, Atlanta, GeorgiaEirini Nestoridi - Massachusetts Department of Public HealthEleni A Papadopoulos - Birth Defects Registry, New York State Department of Health, Albany, New York, United StatesStephen M Kerr - Boston UniversitySean G Young - University of Arkansas for Medical SciencesFrank DeStefano - Centers for Disease Control and PreventionPaul A Romitti - University of IowaNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- Pharmacoepidemiology and drug safety, Vol.31(8), pp.851-862
- DOI
- 10.1002/pds.5435
- PMID
- 35366035
- PMCID
- PMC10331487
- NLM abbreviation
- Pharmacoepidemiol Drug Saf
- ISSN
- 1053-8569
- eISSN
- 1099-1557
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: DD001223, U01, DD18‐001, DD13‐003, DD09‐001
- Language
- English
- Date published
- 04/02/2022
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984230625002771
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