Journal article
Influenza vaccination during pregnancy and risk of selected major structural congenital heart defects, National Birth Defects Prevention Study 2006-2011
Birth defects research, Vol.115(1), pp.88-95
01/01/2023
DOI: 10.1002/bdr2.2114
PMCID: PMC10100249
PMID: 36369789
Appears in UI Libraries Support Open Access
Abstract
BACKGROUND Although results from studies of first-trimester influenza vaccination and congenital heart defects (CHDs) have been reassuring, data are limited for specific CHDs. METHODS We assessed associations between reported maternal influenza vaccination, 1 month before pregnancy (B1) through end of third pregnancy month (P3), and specific CHDs using data from a multisite, population-based case-control study. Analysis included 2,982 case children diagnosed with a simple CHD (no other cardiac involvement with or without extracardiac defects) and 4,937 control children without a birth defect with estimated delivery dates during 2006-2011. For defects with ≥5 exposed case children, we used logistic regression to estimate propensity score-adjusted odds ratios (aORs) and 95% confidence intervals (CIs), adjusting for estimated delivery year and season; plurality; and maternal age at delivery, race/ethnicity, low folate intake, and smoking and alcohol use during B1P3. RESULTS Overall, 124 (4.2%) simple CHD case mothers and 197 (4.0%) control mothers reported influenza vaccination from 1 month before through the third pregnancy month. The aOR for any simple CHD was 0.97 (95% CI: 0.76-1.23). Adjusted ORs for specific simple CHDs ranged from 0.62 for hypoplastic left heart syndrome to 2.34 for total anomalous pulmonary venous return (TAPVR). All adjusted CIs included the null except for TAPVR. CONCLUSIONS Although we cannot fully exclude that exposure misclassification may have masked risks for some CHDs, findings add to existing evidence supporting the safety of inactivated influenza vaccination during pregnancy. The TAPVR result may be due to chance, but it may help inform future studies.
Details
- Title: Subtitle
- Influenza vaccination during pregnancy and risk of selected major structural congenital heart defects, National Birth Defects Prevention Study 2006-2011
- Creators
- Kristin Palmsten - HealthPartnersJonathan Suhl - University of IowaKristin M Conway - University of IowaElyse O Kharbanda - HealthPartnersThomas D Scholz - University of IowaElizabeth C Ailes - National Center on Birth Defects and Developmental DisabilitiesJanet D Cragan - National Center on Birth Defects and Developmental DisabilitiesEirini Nestoridi - Massachusetts Department of Public HealthEleni A Papadopoulos - New York State Department of HealthStephen M Kerr - Boston UniversitySean G Young - University of Arkansas for Medical SciencesChristine Olson - Immunization Safety Office Centers for Disease Control and Prevention Atlanta Georgia USAPaul A Romitti - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Birth defects research, Vol.115(1), pp.88-95
- DOI
- 10.1002/bdr2.2114
- PMID
- 36369789
- PMCID
- PMC10100249
- NLM abbreviation
- Birth Defects Res
- eISSN
- 2472-1727
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: PA 96043, PA 02081, FOA DD09‐001, FOA DD13‐003, NOFO DD18‐001
- Language
- English
- Electronic publication date
- 11/11/2022
- Date published
- 01/01/2023
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics; Epidemiology; Biostatistics; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health
- Record Identifier
- 9984317369702771
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