Journal article
Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?
Neuroscience and biobehavioral reviews, Vol.131, pp.704-721
10/05/2021
DOI: 10.1016/j.neubiorev.2021.10.002
PMCID: PMC8642304
PMID: 34624366
Abstract
•The infralimbic cortex (IL) updates relationships between cues and behaviors.•The IL regulates the extinction and ongoing inhibition of certain behaviors.•Overtraining alters how IL mediates behaviors.•Heterogeneous IL neuronal ensembles control opposing behaviors.•Distinct inputs, outputs, and local microcircuitry may define IL ensemble function.
NETT, K.E., and R.T. LaLumiere. Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled? NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2021.-The rodent infralimbic cortex (IL) is implicated in higher order executive functions such as reward seeking and flexible decision making. However, the precise nature of its role in these processes is unclear. Early evidence indicated that the IL promotes the extinction and ongoing inhibition of fear conditioning and cocaine seeking. However, evidence spanning other behavioral domains, such as natural reward seeking and habit-based learning, suggests a more nuanced understanding of IL function. As techniques have advanced and more studies have examined IL function, identifying a unifying explanation for its behavioral function has become increasingly difficult. Here, we discuss evidence of IL function across motivated behaviors, including associative learning, drug seeking, natural reward seeking, and goal-directed versus habit-based behaviors, and emphasize how context-specific encoding and heterogeneous IL neuronal populations may underlie seemingly conflicting findings in the literature. Together, the evidence suggests that a major IL function is to facilitate the encoding and updating of contingencies between cues and behaviors to guide subsequent behaviors.
Details
- Title: Subtitle
- Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?
- Creators
- Kelle E Nett - University of IowaRyan T LaLumiere - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Neuroscience and biobehavioral reviews, Vol.131, pp.704-721
- DOI
- 10.1016/j.neubiorev.2021.10.002
- PMID
- 34624366
- PMCID
- PMC8642304
- NLM abbreviation
- Neurosci Biobehav Rev
- ISSN
- 0149-7634
- eISSN
- 1873-7528
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: DA048055, DA049139
- Language
- English
- Date published
- 10/05/2021
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984185381702771
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