Infrequent Detection of KI, WU and MC Polyomaviruses in Immunosuppressed Individuals with or without Progressive Multifocal Leukoencephalopathy

Xin Dang; Seweryn Bialasiewicz; Michael D. Nissen; Theo P. Sloots; Igor J. Koralnik; Chen S. Tan

doi:10.1371/journal.pone.0016736

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Infrequent Detection of KI, WU and MC Polyomaviruses in Immunosuppressed Individuals with or without Progressive Multifocal Leukoencephalopathy

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Infrequent Detection of KI, WU and MC Polyomaviruses in Immunosuppressed Individuals with or without Progressive Multifocal Leukoencephalopathy

Xin Dang, Seweryn Bialasiewicz, Michael D. Nissen, Theo P. Sloots, Igor J. Koralnik and Chen S. Tan

PloS one, Vol.6(3), pp.e16736-e16736

03/16/2011

DOI: 10.1371/journal.pone.0016736

PMCID: PMC3059210

PMID: 21436884

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Abstract

Conflicting prevalence of newly identified KI(KIPyV), WU(WUPyV) and Merkel Cell Carcinoma(MCPyV) polyomaviruses have been reported in progressive multifocal leukoencephalopathy(PML) patient samples, ranging from 0 to 14.3%. We analyzed the prevalence of these polyomaviruses in cerebrospinal fluid(CSF), peripheral blood mononuclear cells(PBMC), and bone marrow samples from PML patients, immunosuppressed individuals with or without HIV, and multiple sclerosis(MS) patients. Distinct PCR tests for KIPyV, WUPyV and MCPyV DNA performed in two independent laboratories detected low levels of MCPyV DNA only in 1/269 samples. The infrequent detections of these viruses in multiple samples from immunosuppressed individuals including those with PML suggest that their reactivation mechanisms may be different from that of JC polyomavirus (JCPyV) and that they do not play a role in the pathogenesis of PML.

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Title: Subtitle: Infrequent Detection of KI, WU and MC Polyomaviruses in Immunosuppressed Individuals with or without Progressive Multifocal Leukoencephalopathy
Creators: Xin Dang - Beth Israel Deaconess Medical Center
Seweryn Bialasiewicz - Queensland Children’s Medical Research Institute
Michael D. Nissen - Queensland Children’s Medical Research Institute
Theo P. Sloots - Queensland Children’s Medical Research Institute
Igor J. Koralnik - Beth Israel Deaconess Medical Center
Chen S. Tan - Beth Israel Deaconess Medical Center
Resource Type: Journal article
Publication Details: PloS one, Vol.6(3), pp.e16736-e16736
DOI: 10.1371/journal.pone.0016736
PMID: 21436884
PMCID: PMC3059210
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library Science
Number of pages: 5
Grant note: 50006 / Queensland Children's Medical Research Institute K24NS060950 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01 NS 047029; R01 NS 041198; K24 NS 060950 / Public Health Service; United States Department of Health & Human Services; United States Public Health Service P30AI060354 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) P30 AI60354 / Harvard Medical School Center for AIDS Research (CFAR), National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K08 NS 064215-01A1 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Language: English
Date published: 03/16/2011
Academic Unit: Iowa Neuroscience Institute; Internal Medicine
Record Identifier: 9984366364202771

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