Infusion of D1 Dopamine Receptor Agonist into Medial Frontal Cortex Disrupts Neural Correlates of Interval Timing

Krystal L Parker; Rafael N Ruggiero; Nandakumar S Narayanan

doi:10.3389/fnbeh.2015.00294

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Infusion of D1 Dopamine Receptor Agonist into Medial Frontal Cortex Disrupts Neural Correlates of Interval Timing

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Infusion of D1 Dopamine Receptor Agonist into Medial Frontal Cortex Disrupts Neural Correlates of Interval Timing

Krystal L Parker, Rafael N Ruggiero and Nandakumar S Narayanan

Frontiers in behavioral neuroscience, Vol.9(NOVEMBER), pp.294-294

2015

DOI: 10.3389/fnbeh.2015.00294

PMCID: PMC4639709

PMID: 26617499

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Abstract

Medial frontal cortical (MFC) dopamine is essential for the organization of behavior in time. Our prior work indicates that blocking D1 dopamine receptors (D1DR) attenuates temporal processing and low-frequency oscillations by MFC neuronal networks. Here we investigate the effects of focal infusion of the D1DR agonist SKF82958 into MFC during interval timing. MFC D1DR agonist infusion impaired interval timing performance without changing overall firing rates of MFC neurons. MFC ramping patterns of neuronal activity that reflect temporal processing were attenuated following infusion of MFC D1DR agonist. MFC D1DR agonist infusion also altered MFC field potentials by enhancing delta activity between 1 and 4 Hz and attenuating alpha activity between 8 and 15 Hz. These data support the idea that the influence of D1-dopamine signals on frontal neuronal activity adheres to a U-shaped curve, and that cognition requires optimal levels of dopamine in frontal cortex.

Parkinson's disease

cognition

medial frontal cortex

dopamine

interval timing

Details

Title: Subtitle: Infusion of D1 Dopamine Receptor Agonist into Medial Frontal Cortex Disrupts Neural Correlates of Interval Timing
Creators: Krystal L Parker - Neurology, University of Iowa Iowa City, IA, USA
Rafael N Ruggiero - Neurology, University of Iowa Iowa City, IA, USA
Nandakumar S Narayanan - Neurology, University of Iowa Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Frontiers in behavioral neuroscience, Vol.9(NOVEMBER), pp.294-294
DOI: 10.3389/fnbeh.2015.00294
PMID: 26617499
PMCID: PMC4639709
NLM abbreviation: Front Behav Neurosci
ISSN: 1662-5153
eISSN: 1662-5153
Publisher: Switzerland
Grant note: R01 NS089470 / NINDS NIH HHS K01 MH106824 / NIMH NIH HHS
Language: English
Date published: 2015
Academic Unit: Neurology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984003990702771

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