Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements

Matt D Ampleman; Andrés Martinez; Jeanne DeWall; Dorothea F K Rawn; Keri C Hornbuckle; Peter S Thorne

doi:10.1021/es5048039

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Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements

Journal article

Open access

Peer reviewed

Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements

Matt D Ampleman, Andrés Martinez, Jeanne DeWall, Dorothea F K Rawn, Keri C Hornbuckle and Peter S Thorne

Environmental science & technology, Vol.49(2), pp.1156-1164

01/20/2015

DOI: 10.1021/es5048039

PMCID: PMC4303332

PMID: 25510359

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Abstract

Polychlorinated biphenyls (PCBs) are a group of 209 persistent organic pollutants, whose documented carcinogenic, neurological, and respiratory toxicities are expansive and growing. However, PCB inhalation exposure assessments have been lacking for North American ambient conditions and lower-chlorinated congeners. We assessed congener-specific inhalation and dietary exposure for 78 adolescent children and their mothers (n = 68) in the Airborne Exposure to Semi-volatile Organic Pollutants (AESOP) Study. Congener-specific PCB inhalation exposure was modeled using 293 measurements of indoor and outdoor airborne PCB concentrations at homes and schools, analyzed via tandem quadrupole GS-MS/MS, combined with questionnaire data from the AESOP Study. Dietary exposure was modeled using Canadian Total Diet Survey PCB concentrations and National Health and Nutrition Examination Survey (NHANES) food ingestion rates. For ∑PCB, dietary exposure dominates. For individual lower-chlorinated congeners (e.g., PCBs 40+41+71, 52), inhalation exposure was as high as one-third of the total (dietary+inhalation) exposure. ∑PCB inhalation (geometric mean (SE)) was greater for urban mothers (7.1 (1.2) μg yr(–1)) and children (12.0 (1.2) μg yr(–1)) than for rural mothers (2.4 (0.4) μg yr(–1)) and children (8.9 (0.3) μg yr(–1)). Schools attended by AESOP Study children had higher indoor PCB concentrations than did homes, and account for the majority of children’s inhalation exposure.

Housing

Canada

Polychlorinated Biphenyls - analysis

Environmental Pollutants

Nutrition Surveys

Humans

Middle Aged

Chlorine - analysis

Male

Inhalation Exposure - analysis

Environmental Exposure - analysis

Urban Population

Mothers

Tandem Mass Spectrometry

Polychlorinated Biphenyls - adverse effects

Diet

Rural Population

Adolescent

Adult

Environment

Female

Schools

Cohort Studies

Quality Control

ISRP Project 7

ISRP Project 7 2015-2020

ISRP Project 4 2015-2020

Analytical Core

Details

Title: Subtitle: Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements
Creators: Matt D Ampleman
Andrés Martinez
Jeanne DeWall
Dorothea F K Rawn
Keri C Hornbuckle
Peter S Thorne
Resource Type: Journal article
Publication Details: Environmental science & technology, Vol.49(2), pp.1156-1164
Publisher: United States
DOI: 10.1021/es5048039
PMID: 25510359
PMCID: PMC4303332
ISSN: 0013-936X
eISSN: 1520-5851
Grant note: P42 ES013661 / NIEHS NIH HHS P30 ES005605 / NIEHS NIH HHS
Language: English
Date published: 01/20/2015
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health; IIHR--Hydroscience and Engineering; Iowa Superfund Research Program
Record Identifier: 9983806272602771

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