Journal article
Inherited bleeding disorders in oral procedures. Assessment of prophylactic and therapeutic protocols: a scoping review
Australian dental journal, Vol.66(2), pp.150-158
06/01/2021
DOI: 10.1111/adj.12813
PMID: 33336389
Abstract
Background: This scoping review aimed to map available evidence regarding minor/major oral procedures in patients with inherited bleeding disorders (IBDs).
Methods: Studies in medicine or dentistry that reported minor and major oral procedures in individuals presenting IBDs (e.g. haemophilia A or B, von Willebrand disease) were selected. Search and screening were performed in PubMed/Medline, Scopus, Web of Science and Cochrane Library by two independent researchers.
Results: Initial search yielded 4152 citations, of which 257 were included in the final analysis. Most of the evidence for prophylaxis use was derived from observational studies and the most-commonly reported prophylactic protocols were fresh frozen plasma and factor VIII concentrate. A considerable number of studies reported postoperative complications and hospitalizations.
Conclusion: The present study identified that (1) there is room for new studies to assess the use of antifibrinolytic agents with no factor replacement; (2) to date, the use of factor replacement therapy is the most indicated approach when treating patients with IBDs with adjunct systemic or local antifibrinolytic agents to reduce post-operative complications; and (3) there is a critical need for high-quality evidence studies since much of the conclusions of the included studies are not supported by statistical analysis.
Details
- Title: Subtitle
- Inherited bleeding disorders in oral procedures. Assessment of prophylactic and therapeutic protocols: a scoping review
- Creators
- Mateus de Azevedo Kinalski - Universidade Federal de PelotasRafael Sarkis-Onofre - Atitus EducaçãoMateus Bertolini Fernandes dos Santos - Universidade Federal de Pelotas
- Resource Type
- Journal article
- Publication Details
- Australian dental journal, Vol.66(2), pp.150-158
- DOI
- 10.1111/adj.12813
- PMID
- 33336389
- NLM abbreviation
- Aust Dent J
- ISSN
- 0045-0421
- eISSN
- 1834-7819
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- 001 / Coordination for the Improvement of Higher Education Personnel (CAPES); Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Meriodional Foundation (Passo Fundo - Brazil)
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Prosthodontics
- Record Identifier
- 9984945915002771
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