Inherited genetic variation and overall survival following follicular lymphoma

Todd M Gibson; Sophia S Wang; James R Cerhan; Matthew J Maurer; Patricia Hartge; Thomas M Habermann; Scott Davis; Wendy Cozen; Charles F Lynch; Richard K Severson; Nathaniel Rothman; Stephen J Chanock; Lindsay M Morton

doi:10.1002/ajh.23184

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Inherited genetic variation and overall survival following follicular lymphoma

Journal article

Open access

Peer reviewed

Inherited genetic variation and overall survival following follicular lymphoma

Todd M Gibson, Sophia S Wang, James R Cerhan, Matthew J Maurer, Patricia Hartge, Thomas M Habermann, Scott Davis, Wendy Cozen, Charles F Lynch, Richard K Severson, …

American journal of hematology, Vol.87(7), pp.724-726

07/2012

DOI: 10.1002/ajh.23184

PMCID: PMC3392094

PMID: 22473939

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Abstract

Follicular lymphoma (FL) has variable progression and survival, and improved identification of patients at high risk for progression would aid in identifying patients most likely to benefit from alternative therapy.In a sample of 244 FL cases identified during a population-based case-control study of non-Hodgkin lymphoma (NHL), we examined 6,679 tag SNPs in 488 gene regions for associations with overall FL survival. Over a median follow-up of 89 months with 65 deaths in this preliminary study, we identified 5 gene regions (BMP7, GALNT12,DUSP2, GADD45B, and ADAM17) that were associated with overall survival from FL. Results did not meet the criteria for statistical significance after adjustment for multiple hypothesis testing. These results,which support a role for host factors in determining the variable progression of FL, serve as an initial examination that can inform future studies of genetic variation and FL survival. However, they require replication in independent populations, as well as assessment in rituximab-treated patients.

United States - epidemiology

SEER Program

Prognosis

Follow-Up Studies

Genetic Association Studies

Humans

Middle Aged

Lymphoma, Follicular - diagnosis

Lymphoma, Follicular - mortality

Male

Case-Control Studies

Genetic Variation

Young Adult

Lymphoma, Follicular - blood

Lymphoma, Follicular - genetics

Survival Analysis

Aged, 80 and over

Adult

Female

Aged

Polymorphism, Single Nucleotide

Details

Title: Subtitle: Inherited genetic variation and overall survival following follicular lymphoma
Creators: Todd M Gibson - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA. gibsontm@mail.nih.gov
Sophia S Wang
James R Cerhan
Matthew J Maurer
Patricia Hartge
Thomas M Habermann
Scott Davis
Wendy Cozen
Charles F Lynch
Richard K Severson
Nathaniel Rothman
Stephen J Chanock
Lindsay M Morton
Resource Type: Journal article
Publication Details: American journal of hematology, Vol.87(7), pp.724-726
Publisher: United States
DOI: 10.1002/ajh.23184
PMID: 22473939
PMCID: PMC3392094
ISSN: 0361-8609
eISSN: 1096-8652
Grant note: N01 PC067010 / NCI NIH HHS N02-PC-71105 / NCI NIH HHS N01-PC-67009 / NCI NIH HHS P30 CA015704 / NCI NIH HHS Z99 CA999999 / Intramural NIH HHS N01 PC067008 / NCI NIH HHS R01-CA96704 / NCI NIH HHS N01 PC065064 / NCI NIH HHS N01 PC067009 / NCI NIH HHS R01 CA096704 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
Language: English
Date published: 07/2012
Academic Unit: Epidemiology
Record Identifier: 9983995138602771

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