Journal article
Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration
Visual neuroscience, Vol.22(5), pp.637-648
09/2005
DOI: 10.1017/S0952523805225130
PMID: 16332275
Abstract
The glaucomas are neurodegenerative diseases involving death of
retinal ganglion cells and optic nerve head excavation. A major risk
factor for this neurodegeneration is a harmfully elevated intraocular
pressure (IOP). Human glaucomas are typically complex, progressive
diseases that are prevalent in the elderly. Family history and genetic
factors are clearly important in human glaucoma. Mouse studies have proven
helpful for investigating the genetic and mechanistic basis of complex
diseases. We previously reported inherited, age-related progressive
glaucoma in DBA/2J mice. Here, we report our updated findings from
studying the disease in a large number of DBA/2J mice. The period when
mice have elevated IOP extends from 6 months to 16 months, with 8–9
months representing an important transition to high IOP for many mice.
Optic nerve degeneration follows IOP elevation, with the majority of optic
nerves being severely damaged by 12 months of age. This information should
help with the design of experiments, and we present the data in a manner
that will be useful for future studies of retinal ganglion cell
degeneration and optic neuropathy.
Details
- Title: Subtitle
- Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration
- Creators
- RICHARD T LIBBY - The Jackson Laboratory, Bar HarborMICHAEL G ANDERSON - The Jackson Laboratory, Bar HarborIOK-HOU PANG - Alcon Research, Ltd. Ft. WorthZACHARY H ROBINSON - The Jackson Laboratory, Bar HarborOLGA V SAVINOVA - The Jackson Laboratory, Bar HarborI. MIHAI COSMA - The Jackson Laboratory, Bar HarborAMY SNOW - The Jackson Laboratory, Bar HarborLAWRISTON A WILSON - The Jackson Laboratory, Bar HarborRICHARD S SMITH - The Jackson Laboratory, Bar HarborABBOT F CLARK - Alcon Research, Ltd. Ft. WorthSIMON W.M JOHN - The Jackson Laboratory, Bar Harbor
- Resource Type
- Journal article
- Publication Details
- Visual neuroscience, Vol.22(5), pp.637-648
- Publisher
- Cambridge University Press; New York, USA
- DOI
- 10.1017/S0952523805225130
- PMID
- 16332275
- ISSN
- 0952-5238
- eISSN
- 1469-8714
- Number of pages
- 12
- Language
- English
- Date published
- 09/2005
- Academic Unit
- Molecular Physiology and Biophysics; Ophthalmology and Visual Sciences
- Record Identifier
- 9984025591702771
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