Journal article
Inherited peripheral neuropathies
Continuum (Minneapolis, Minn.), Vol.17(2 Neurogenetics), pp.294-315
04/2011
DOI: 10.1212/01.CON.0000396963.75069.66
PMID: 22810821
Abstract
Mutations in genes expressed in Schwann cells and the axons they ensheathe cause the hereditary motor and sensory neuropathies, also known as Charcot-Marie-Tooth disease (CMT). More than 40 different genes have been shown to cause inherited neuropathies; chromosomal localizations of many other distinct inherited neuropathies have been mapped, and new genetic causes for inherited neuropathies continue to be discovered. How to keep track of all of these disorders, when to pursue genetic testing, and what tests to order for specific patients are difficult challenges for any neurologist. This review addresses these issues and provides illustrative cases to help in dealing with them. CMT serves as a living system to identify molecules necessary for normal peripheral nervous system (PNS) function. Understanding how these various molecules interact will provide a better understanding of the pathogenesis of peripheral neuropathies in general as well as other neurodegenerative disorders involving the PNS.
Details
- Title: Subtitle
- Inherited peripheral neuropathies
- Creators
- Michael E Shy
- Resource Type
- Journal article
- Publication Details
- Continuum (Minneapolis, Minn.), Vol.17(2 Neurogenetics), pp.294-315
- Publisher
- United States
- DOI
- 10.1212/01.CON.0000396963.75069.66
- PMID
- 22810821
- ISSN
- 1080-2371
- eISSN
- 1538-6899
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020648602771
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