Journal article
Inhibiting Sublimation of Thymol by Cocrystallization
Journal of pharmaceutical sciences, Vol.112(1), pp.350-353
01/2023
DOI: 10.1016/j.xphs.2022.10.019
Abstract
A thymol:4,4’-dipyridyl (2:1) cocrystal (Form I) is reported to suppress thymol sublimation. The cocrystal was prepared via solution-mediated phase transformation and its structure is sustained by O-H (phenol) ··· N (pyridyl) hydrogen bonds between two individual components. A cocrystal polymorph (Form II) was formed via solid state transformation or via vapor phase upon heating. Using gravimetry analysis, it was demonstrated that cocrystal Form I decreased the sublimation rate of thymol by 38-fold. This study demonstrates that cocrystallization is an effective approach to reduce vapor pressure and sublimation of solids, thus achieving odor-masking
Details
- Title: Subtitle
- Inhibiting Sublimation of Thymol by Cocrystallization
- Creators
- Hui ZuRodger F HenryGeoff G Z ZhangLeonard R MacGillivray
- Resource Type
- Journal article
- Publication Details
- Journal of pharmaceutical sciences, Vol.112(1), pp.350-353
- DOI
- 10.1016/j.xphs.2022.10.019
- ISSN
- 0022-3549
- eISSN
- 1520-6017
- Language
- English
- Electronic publication date
- 10/21/2022
- Date published
- 01/2023
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984307660202771
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