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Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
Journal article   Open access   Peer reviewed

Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

Daniel B Dorman, Joanna Jędrzejewska-Szmek and Kim T Blackwell
eLife, Vol.7, e38588
10/25/2018
DOI: 10.7554/eLife.38588
PMCID: PMC6235562
PMID: 30355449
url
https://doi.org/10.7554/eLife.38588View
Published (Version of record) Open Access

Abstract

Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on data from rodents of both sexes, to investigate how spatiotemporally clustered and distributed excitatory and inhibitory inputs affect spine calcium. We demonstrate that coordinated excitatory synaptic inputs evoke enhanced calcium elevation specific to stimulated spines, with lower but physiologically relevant calcium elevation in nearby non-stimulated spines. Results further show a novel and important function of inhibition-to enhance the difference in calcium between stimulated and non-stimulated spines. These findings suggest that spine calcium dynamics encode synaptic input patterns and may serve as a signal for both stimulus-specific potentiation and heterosynaptic depression, maintaining balanced activity in a dendritic branch while inducing pattern-specific plasticity.
 Action Potentials Calcium - metabolism Computer Simulation Dendritic Spines - metabolism Excitatory Postsynaptic Potentials Ion Channels - metabolism Models, Neurological Neural Inhibition - physiology Neurons - metabolism Synapses - metabolism

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