Journal article
Inhibition of BMP9 Induced Bone Formation by Salicylic-acid Polymer Capping
MRS advances, Vol.4(64), pp.3505-3512
12/2019
DOI: 10.1557/adv.2020.61
PMCID: PMC8078835
PMID: 33912355
Abstract
This work focuses on the development of a system to control the formation of bone to complement developments that have enabled potent regeneration of bony tissue. Scaffolds were fabricated with chemically modified RNA encoding for bone morphogenetic protein-9 (cmBMP9) and capped with salicylic acid (SA)-containing polymer (SAPAE). The goal was to determine if SAPAE could inhibit the formation of bone in a pilot animal study since cmBMP9 has been demonstrated to be highly effective in regenerating bone in a rat calvarial defect model. The results indicated that cmBMP9 increased bone formation (30% increase in area covered compared to control) and that SAPAE trended toward reducing the bone formation. These results suggest SAPAE could be useful as a chemical agent in reducing unwanted bone formation in implants loaded with cmBMP9.
Details
- Title: Subtitle
- Inhibition of BMP9 Induced Bone Formation by Salicylic-acid Polymer Capping
- Creators
- Timothy M Acri - University of Iowa, College of Pharmacy, 115 S. Grand Avenue Iowa City, IowaNoah Z Laird - University of Iowa, College of Pharmacy, 115 S. Grand Avenue Iowa City, IowaLiu Hong - University of Iowa, College of Dentistry, 801 Newton Road Iowa City, IowaJaidev L Chakka - University of Iowa, College of Pharmacy, 115 S. Grand Avenue Iowa City, IowaKyungsup Shin - University of Iowa, College of Dentistry, 801 Newton Road Iowa City, IowaSatheesh Elangovan - University of Iowa, College of Dentistry, 801 Newton Road Iowa City, IowaAliasger K Salem - University of Iowa, College of Dentistry, 801 Newton Road Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- MRS advances, Vol.4(64), pp.3505-3512
- DOI
- 10.1557/adv.2020.61
- PMID
- 33912355
- PMCID
- PMC8078835
- NLM abbreviation
- MRS Adv
- ISSN
- 2059-8521
- eISSN
- 2059-8521
- Grant note
- R21 DE024206 / NIDCR NIH HHS
- Language
- English
- Date published
- 12/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthodontics; Pharmaceutical Sciences and Experimental Therapeutics; Prosthodontics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Periodontics
- Record Identifier
- 9984216578602771
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