Journal article
Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody
The Journal of experimental medicine, Vol.178(1), pp.257-264
07/01/1993
DOI: 10.1084/jem.178.1.257
PMID: 8315381
Abstract
The effects of interleukin 7 (IL-7) on the growth and differentiation of murine B cell progenitors has been well characterized using in vitro culture methods. We have investigated the role of IL-7 in vivo using a monoclonal antibody that neutralizes IL-7. We find that treatment of mice with this antibody completely inhibits the development of B cell progenitors from the pro-B cell stage forward. We also provide evidence that all peripheral B cells, including those of the B-1 and conventional lineages, are derived from IL-7-dependent precursors. The results are consistent with the rapid turnover of B cell progenitors in the marrow, but a slow turnover of mature B cells in the periphery. In addition to effects on B cell development, anti-IL-7 treatment substantially reduced thymus cellularity, affecting all major thymic subpopulations.
Details
- Title: Subtitle
- Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody
- Creators
- Kenneth H Grabstein - Immunex Research and Development Corporation, Seattle, Washington 98101Thomas J Waldschmidt - Immunex Research and Development Corporation, Seattle, Washington 98101Fred D Finkelman - Immunex Research and Development Corporation, Seattle, Washington 98101Bruce W Hess - Immunex Research and Development Corporation, Seattle, Washington 98101Alan R Alpert - Immunex Research and Development Corporation, Seattle, Washington 98101Norman E Boiani - Immunex Research and Development Corporation, Seattle, Washington 98101Anthony E Namen - Immunex Research and Development Corporation, Seattle, Washington 98101Philip J Morrissey - Immunex Research and Development Corporation, Seattle, Washington 98101
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.178(1), pp.257-264
- DOI
- 10.1084/jem.178.1.257
- PMID
- 8315381
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Language
- English
- Date published
- 07/01/1993
- Academic Unit
- Pathology
- Record Identifier
- 9984047661602771
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