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Inhibition of venoconstrictor responses by prostaglandin E1
Journal article   Peer reviewed

Inhibition of venoconstrictor responses by prostaglandin E1

Phyllis R Hedwall, Wadie A Abdel-Sayed, Phillip G Schmid and François M Abboud
Proceedings of the Society for Experimental Biology and Medicine, Vol.135(3), pp.757-759
12/1970
DOI: 10.3181/00379727-135-35137
PMID: 4321033

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Abstract

PGE1 caused venodilatation in the isolated perfused canine gracilis muscle but not in the perfused hindpaw. Venoconstrictor responses to nerve stimulation, norepinephrine, and angiotensin were inhibited significantly and uniformly in the paw but not in the muscle. The results indicate that inhibition of venoconstrictor responsiveness by PGE1 is not associated with nor dependent upon a direct dilator action of the prostaglandin.
Norepinephrine - antagonists & inhibitors Electric Stimulation Vasodilator Agents - pharmacology Prostaglandins - pharmacology Angiotensin II - antagonists & inhibitors Male Veins - drug effects Venous Pressure - drug effects Animals Perfusion Muscles - drug effects Dogs Hindlimb - drug effects

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