Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer

Y Anzai; Keith E Blackwell; S L Hirschowitz; John W. Rogers; Yutaka Sato; William T C Yuh; V M Runge; Marie R Morris; Stuart J McLachlan; R B Lufkin

doi:10.1148/radiology.192.3.7520182

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Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer

Journal article

Peer reviewed

Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer

Y Anzai, Keith E Blackwell, S L Hirschowitz, John W. Rogers, Yutaka Sato, William T C Yuh, V M Runge, Marie R Morris, Stuart J McLachlan and R B Lufkin

Radiology, Vol.192(3), pp.709-715

09/1994

DOI: 10.1148/radiology.192.3.7520182

PMID: 7520182

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Abstract

To investigate the efficacy of magnetic resonance (MR) imaging with dextran-coated superparamagnetic iron oxide in the differentiation of metastatic and benign nodes in patients with head and neck cancer. MR imaging was performed before and after intravenous administration of iron oxide in 12 patients. Ninety-one pathologically proved nodes were visually analyzed, and 66 lymph nodes were quantitatively analyzed by measuring signal intensity in visually selected regions of interest. Forty of 42 histologically proved metastatic nodes and 41 of 49 benign nodes were detected, yielding 95% sensitivity and 84% specificity. The signal intensity ratio of benign nodes was substantially lower than that of metastatic nodes, indicating better differentiation of metastatic and benign nodes. Furthermore, 13 of 14 normal-sized nodes were detected. MR imaging with iron oxide can enable specific differentiation of metastatic and benign nodes in patients with head and neck cancer. This agent may potentially enhance the detection of metastatic lymph nodes and deserves further investigation.

Iron

Magnetic Resonance Imaging

Lymphatic Metastasis - diagnosis

Lymph Nodes - pathology

Humans

Middle Aged

Male

Oxides

Head and Neck Neoplasms - pathology

Ferrosoferric Oxide

Dextrans

Lymphatic Metastasis - pathology

Adult

Female

Aged

Magnetite Nanoparticles

Details

Title: Subtitle: Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer
Creators: Y Anzai - Department of Radiological Sciences, University of California, Los Angeles 90024-1721
Keith E Blackwell
S L Hirschowitz
John W. Rogers
Yutaka Sato
William T C Yuh
V M Runge
Marie R Morris
Stuart J McLachlan
R B Lufkin
Resource Type: Journal article
Publication Details: Radiology, Vol.192(3), pp.709-715
Publisher: United States
DOI: 10.1148/radiology.192.3.7520182
PMID: 7520182
ISSN: 0033-8419
eISSN: 1527-1315
Language: English
Date published: 09/1994
Academic Unit: Radiology; Stead Family Department of Pediatrics
Record Identifier: 9984051732702771

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