Initiation of a coronavirus vaccine library

Dory Kovacs; Gurpreet Brar; Simon J Anthony; Lin-Fa Wang; Edward C Holmes; Linda J Saif; Volker Gerdts; Leo Poon; Stanley Perlman; Joris Vandeputte; Christian Drosten; Heather Louise Wells; Javier Castillo-Olivares; Trevor Brasel; Timothy Endy; Ann-Muriel Steff; Georges Thiry; Nadia Cohen

doi:10.1016/j.vaccine.2025.128140

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Initiation of a coronavirus vaccine library

Journal article

Peer reviewed

Initiation of a coronavirus vaccine library

Dory Kovacs, Gurpreet Brar, Simon J Anthony, Lin-Fa Wang, Edward C Holmes, Linda J Saif, Volker Gerdts, Leo Poon, Stanley Perlman, Joris Vandeputte, …

Vaccine, Vol.72, 128140

02/06/2026

DOI: 10.1016/j.vaccine.2025.128140

PMID: 41422789

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Abstract

Coronaviruses (CoVs) continue to pose a global health threat as they spill over from animal hosts to humans. The Coalition for Epidemic Preparedness Innovations (CEPI) is a global partnership focused on vaccine research and development. CEPI's CoV Vaccine Library initiative aims to generate knowledge and tools to accelerate vaccine development against emergent CoVs, prioritizing those with the highest assessed risk of spillover, vaccine feasibility, and phylogenetic coverage. Based on expert consultations and published data, we developed a prioritized list of 26 CoVs to serve as a foundation for building a knowledge base to support future vaccine efforts. As a first step, in silico designs will be used to develop stabilized spike antigens for select targets. These antigens will be tested for pre-clinical immunogenicity and breadth using different vaccine modalities. Assays, tools, and data generated will nucleate an open-access library and serve as a starting point for emergent CoV vaccine development.

Vaccine development

Coronaviruses

Zoonotic coronaviruses

Pandemic preparedness

Vaccine library

Details

Title: Subtitle: Initiation of a coronavirus vaccine library
Creators: Dory Kovacs - Coalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway. Electronic address: dory.kovacs@cepi.net
Gurpreet Brar - Coalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway
Simon J Anthony - University of California, Davis
Lin-Fa Wang - Duke-NUS Medical School
Edward C Holmes - The University of Sydney
Linda J Saif - The Ohio State University
Volker Gerdts - University of Saskatchewan
Leo Poon - University of Hong Kong
Stanley Perlman - University of Iowa
Joris Vandeputte - VacciM/IABS (International Alliance for Biological Standardization), Belgium, Switzerland
Christian Drosten - Charité - Universitätsmedizin Berlin
Heather Louise Wells - University of California, Davis
Javier Castillo-Olivares - Coalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway
Trevor Brasel - Coalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway
Timothy Endy - Coalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway
Ann-Muriel Steff - Coalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway
Georges Thiry - Coalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway
Nadia Cohen - Coalition for Epidemic Preparedness Innovations (CEPI), Oslo, Norway
Resource Type: Journal article
Publication Details: Vaccine, Vol.72, 128140
DOI: 10.1016/j.vaccine.2025.128140
PMID: 41422789
NLM abbreviation: Vaccine
ISSN: 0264-410X
eISSN: 1873-2518
Publisher: Elsevier
Grant note: Coalition for Epidemic Preparedness Innovations (CEPI)
This work was funded by the Coalition for Epidemic Preparedness Innovations (CEPI) .
Language: English
Electronic publication date: 12/20/2025
Date published: 02/06/2026
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9985093887802771

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