Journal article
Innate Immunity and Asthma Exacerbations: Insights From Human Models
Immunological reviews, Vol.330(1), e70016
03/01/2025
DOI: 10.1111/imr.70016
PMCID: PMC11922041
PMID: 40087882
Abstract
Asthma is a common chronic respiratory disease characterized by the presence of airway inflammation, airway hyperresponsiveness, and mucus hypersecretion. Repeated asthma exacerbations can lead to progressive airway remodeling and irreversible airflow obstruction. Thus, understanding and preventing asthma exacerbations are of paramount importance. Although multiple endotypes exist, asthma is most often driven by type 2 airway inflammation. New therapies that target specific type 2 mediators have been shown to reduce the frequency of asthma exacerbations but are incompletely effective in a significant number of asthmatics. Furthermore, it remains unknown whether current treatments lead to sustained changes in the airway or if targeting additional pathways may be necessary to achieve asthma remission. Activation of innate immunity is the initial event in the inflammatory sequence that occurs during an asthma exacerbation. However, there continue to be critical gaps in our understanding of the innate immune response to asthma exacerbating factors. In this review, we summarize the current understanding of the role of innate immunity in asthma exacerbations and the methods used to study them. We also identify potential novel therapeutic targets for asthma and future areas for investigation.Asthma is a common chronic respiratory disease characterized by the presence of airway inflammation, airway hyperresponsiveness, and mucus hypersecretion. Repeated asthma exacerbations can lead to progressive airway remodeling and irreversible airflow obstruction. Thus, understanding and preventing asthma exacerbations are of paramount importance. Although multiple endotypes exist, asthma is most often driven by type 2 airway inflammation. New therapies that target specific type 2 mediators have been shown to reduce the frequency of asthma exacerbations but are incompletely effective in a significant number of asthmatics. Furthermore, it remains unknown whether current treatments lead to sustained changes in the airway or if targeting additional pathways may be necessary to achieve asthma remission. Activation of innate immunity is the initial event in the inflammatory sequence that occurs during an asthma exacerbation. However, there continue to be critical gaps in our understanding of the innate immune response to asthma exacerbating factors. In this review, we summarize the current understanding of the role of innate immunity in asthma exacerbations and the methods used to study them. We also identify potential novel therapeutic targets for asthma and future areas for investigation.
Details
- Title: Subtitle
- Innate Immunity and Asthma Exacerbations: Insights From Human Models
- Creators
- Jehan Alladina - Massachusetts General HospitalBenjamin D Medoff - Massachusetts General HospitalJosalyn L Cho
- Resource Type
- Journal article
- Publication Details
- Immunological reviews, Vol.330(1), e70016
- DOI
- 10.1111/imr.70016
- PMID
- 40087882
- PMCID
- PMC11922041
- NLM abbreviation
- Immunol Rev
- ISSN
- 1600-065X
- eISSN
- 1600-065X
- Publisher
- WILEY
- Grant note
- National Heart, Lung, and Blood Institute: K08 HL173572, R21 AI176580, U01 HL175384, UH2 AI44434 National Institutes of Health
This work was supported by the National Institutes of Health-K08 HL173572 to J.A., R21 AI176580 and U01 HL175384 to B.D.M., and UH2 AI44434 to J.L.C.
- Language
- English
- Date published
- 03/01/2025
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984799685502771
Metrics
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