Journal article
Innate immune and inflammatory responses to SARS-CoV-2: implications for COVID-19
Cell host & microbe, Vol.29(7), pp.1052-1062
07/14/2021
DOI: 10.1016/j.chom.2021.05.004
PMCID: PMC8126603
PMID: 34022154
Abstract
COVID-19 can result in severe disease characterized by significant immunopathology that is spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive response. A limited and delayed interferon I (IFN-I) and IFN-III response results in exacerbated proinflammatory cytokine production and in extensive cellular infiltrates in the respiratory tract, resulting in lung pathology. The development of effective therapeutics for patients with severe COVID-19 depends on our understanding the pathological elements of this unbalanced innate immune response. Here, we review the mechanisms by which SARS-CoV-2 both activates and antagonizes the IFN and inflammatory response following infection, how a dysregulated cytokine and cellular response contributes to immune-mediated pathology in COVID-19, and therapeutic strategies that target elements of the innate response.\nLowery et al. review the mechanisms by which SARS-CoV-2 activates and antagonizes the interferon and inflammatory response following infection, how a dysregulated cytokine and cellular response contributes to immune-mediated pathology in COVID-19, and therapeutic strategies that target elements of the innate response.
Details
- Title: Subtitle
- Innate immune and inflammatory responses to SARS-CoV-2: implications for COVID-19
- Creators
- Shea A Lowery - Department of Microbiology and ImmunologyAlan Sariol - Interdisciplinary Program in ImmunologyStanley Perlman - Department of Microbiology and Immunology
- Resource Type
- Journal article
- Publication Details
- Cell host & microbe, Vol.29(7), pp.1052-1062
- DOI
- 10.1016/j.chom.2021.05.004
- PMID
- 34022154
- PMCID
- PMC8126603
- NLM abbreviation
- Cell Host Microbe
- ISSN
- 1931-3128
- eISSN
- 1934-6069
- Publisher
- Published by Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: AI060699, T32 AI00753 3, RO1 AI129269
- Language
- English
- Date published
- 07/14/2021
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984080378402771
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