Journal article
Innate immune responses in pneumonia
Pneumonia, Vol.15(1), 4
02/25/2023
DOI: 10.1186/s41479-023-00106-8
PMCID: PMC9957695
PMID: 36829255
Abstract
The lungs are an immunologically unique environment; they are exposed to innumerable pathogens and particulate matter daily. Appropriate clearance of pathogens and response to pollutants is required to prevent overwhelming infection, while preventing tissue damage and maintaining efficient gas exchange. Broadly, the innate immune system is the collection of immediate, intrinsic immune responses to pathogen or tissue injury. In this review, we will examine the innate immune responses of the lung, with a particular focus on their role in pneumonia. We will discuss the anatomic barriers and antimicrobial proteins of the lung, pathogen and injury recognition, and the role of leukocytes (macrophages, neutrophils, and innate lymphocytes) and lung stromal cells in innate immunity. Throughout the review, we will focus on new findings in innate immunity as well as features that are unique to the lung.
Details
- Title: Subtitle
- Innate immune responses in pneumonia
- Creators
- Filiz T Korkmaz - University of Massachusetts Chan Medical SchoolKatrina E Traber - Boston University
- Resource Type
- Journal article
- Publication Details
- Pneumonia, Vol.15(1), 4
- DOI
- 10.1186/s41479-023-00106-8
- PMID
- 36829255
- PMCID
- PMC9957695
- ISSN
- 2200-6133
- eISSN
- 2200-6133
- Grant note
- K99 HL159258 / NHLBI NIH HHS R01 GM120060 / NIGMS NIH HHS T32 HL007035 / NHLBI NIH HHS R01 HL158732 / NHLBI NIH HHS F32 HL147461 / NHLBI NIH HHS K08 HL130582 / NHLBI NIH HHS
- Language
- English
- Date published
- 02/25/2023
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984696682202771
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