Journal article
Innate immunity against Leishmania infections
Cellular microbiology, Vol.17(9), pp.1286-1294
09/2015
DOI: 10.1111/cmi.12484
PMCID: PMC4698274
PMID: 26249747
Abstract
Leishmaniasis is a major health problem that affects more than 300 million people throughout the world. The morbidity associated with the disease causes serious economic burden in Leishmania endemic regions. Despite the morbidity and economic burden associated with Leishmaniasis, this disease rarely gets noticed and is still categorized under neglected tropical diseases. The lack of research combined with the ability of Leishmania to evade immune recognition has rendered our efforts to design therapeutic treatments or vaccines challenging. Herein, we review the literature on Leishmania from innate immune perspective and discuss potential problems as well as solutions and future directions that could aid in identifying novel therapeutic targets to eliminate this parasite.
Details
- Title: Subtitle
- Innate immunity against Leishmania infections
- Creators
- Prajwal Gurung - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USAThirumala-Devi Kanneganti - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA
- Resource Type
- Journal article
- Publication Details
- Cellular microbiology, Vol.17(9), pp.1286-1294
- DOI
- 10.1111/cmi.12484
- PMID
- 26249747
- PMCID
- PMC4698274
- ISSN
- 1462-5814
- eISSN
- 1462-5822
- Grant note
- R01 AI101935 / NIAID NIH HHS R01 AR056296 / NIAMS NIH HHS AI101935 / NIAID NIH HHS R01 CA163507 / NCI NIH HHS CA163507 / NCI NIH HHS AR056296 / NIAMS NIH HHS
- Language
- English
- Date published
- 09/2015
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094386202771
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