Journal article
Innate immunity in disease
Clinical gastroenterology and hepatology, Vol.12(5), pp.749-755
05/2014
DOI: 10.1016/j.cgh.2014.03.007
PMCID: PMC4083246
PMID: 24632348
Abstract
Cells can innately recognize generic products of viruses, bacteria, fungi, or injured tissue by engagement of pattern recognition receptors. Innate immune cells rapidly respond to this engagement to control commensals, thwart pathogens, and/or prompt repair. Insufficient or excessive activation of the innate immune response results in disease. This review focuses on pattern recognition receptors and cells of the innate immune system that are important for intestinal function. Our improving knowledge pertaining to this important aspect of our immune response is opening potential important new therapeutic opportunities for the treatment of disease.
Details
- Title: Subtitle
- Innate immunity in disease
- Creators
- David E Elliott - Division of Gastroenterology/Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IowaSana S Siddique - Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center, Boston, MassachusettsJoel V Weinstock - Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center, Boston, Massachusetts. Electronic address: jweinstock2@tuftsmedicalcenter.org
- Resource Type
- Journal article
- Publication Details
- Clinical gastroenterology and hepatology, Vol.12(5), pp.749-755
- DOI
- 10.1016/j.cgh.2014.03.007
- PMID
- 24632348
- PMCID
- PMC4083246
- ISSN
- 1542-3565
- eISSN
- 1542-7714
- Grant note
- DK058755 / NIDDK NIH HHS R01 DK091987 / NIDDK NIH HHS DK091987 / NIDDK NIH HHS
- Language
- English
- Date published
- 05/2014
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094678702771
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