Journal article
Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
Nature communications, Vol.12(1), pp.657-657
01/28/2021
DOI: 10.1038/s41467-021-20939-5
PMCID: PMC7844252
PMID: 33510158
Abstract
The sensation of pressure allows us to feel sustained compression and body strain. While our understanding of cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitative sensory evaluations of patients with rare sensory disorders, as well as nerve blocks in typical individuals, to probe the neural and genetic mechanisms for detecting non-painful pressure. We show that the ability to perceive innocuous pressures is lost when myelinated fiber function is experimentally blocked in healthy volunteers and that two patients lacking Aβ fibers are strikingly unable to feel innocuous pressures at all. We find that seven individuals with inherited mutations in the mechanoreceptor PIEZO2 gene, who have major deficits in touch and proprioception, are nearly as good at sensing pressure as healthy control subjects. Together, these data support a role for Aβ afferents in pressure sensation and suggest the existence of an unknown molecular pathway for its detection.
Details
- Title: Subtitle
- Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
- Creators
- Laura K Case - University of California San DiegoJaquette Liljencrantz - University of GothenburgNicholas Madian - National Center for Complementary and Integrative HealthAaron Necaise - National Center for Complementary and Integrative HealthJustin Tubbs - National Center for Complementary and Integrative HealthMicaela McCall - National Center for Complementary and Integrative HealthMegan L Bradson - National Center for Complementary and Integrative HealthMarcin Szczot - National Center for Complementary and Integrative HealthMark H Pitcher - National Center for Complementary and Integrative HealthNima Ghitani - National Center for Complementary and Integrative HealthEleni Frangos - National Center for Complementary and Integrative HealthJonathan Cole - Bournemouth UniversityDiana Bharucha-Goebel - National Institute of Neurological Disorders and StrokeDimah Saade - National Institute of Neurological Disorders and StrokeTracy Ogata - National Institute of Neurological Disorders and StrokeSandra Donkervoort - National Institute of Neurological Disorders and StrokeA Reghan Foley - National Institute of Neurological Disorders and StrokeCarsten G Bönnemann - National Institute of Neurological Disorders and StrokeHåkan Olausson - Linköping UniversityM Catherine Bushnell - National Center for Complementary and Integrative HealthAlexander T Chesler - National Institute of Neurological Disorders and Stroke
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.12(1), pp.657-657
- DOI
- 10.1038/s41467-021-20939-5
- PMID
- 33510158
- PMCID
- PMC7844252
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Language
- English
- Date published
- 01/28/2021
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984354044902771
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