Journal article
Innovations in Clinical Maxillofacial Tissue Engineering and Reconstruction: Cellular Bone Matrix Allografts, Autografts, and Growth Factors
Craniomaxillofacial trauma & reconstruction, Vol.19(2), 18
03/24/2026
DOI: 10.3390/cmtr19020018
PMCID: PMC13108040
PMID: 42029429
Abstract
Reconstruction of craniomaxillofacial (CMF) bony defects requires individualized strategies based on defect characteristics and graft bed biology, with traditional approaches relying on autogenous non-vascularized bone grafts or vascularized free flaps that, while reliable, are associated with donor-site morbidity and operative complexity. Biologically driven reconstructive strategies, including tissue engineering, cellular bone matrix allografts (CBMs), and growth factor adjuncts, have emerged as alternatives or complements to autograft-based reconstruction. This review introduces and details these new innovations with emphasis on the current literature, thus empowering surgeons to enhance their clinical armamentarium.
Details
- Title: Subtitle
- Innovations in Clinical Maxillofacial Tissue Engineering and Reconstruction: Cellular Bone Matrix Allografts, Autografts, and Growth Factors
- Creators
- Jeffrey S. Marschall - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Craniomaxillofacial trauma & reconstruction, Vol.19(2), 18
- DOI
- 10.3390/cmtr19020018
- PMID
- 42029429
- PMCID
- PMC13108040
- ISSN
- 1943-3883
- eISSN
- 1943-3883
- Publisher
- MDPI
- Language
- English
- Date published
- 03/24/2026
- Academic Unit
- Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery
- Record Identifier
- 9985149705802771
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