Journal article
Innovative Application of Fluoro Tagging To Trace Airborne Particulate and Gas-Phase Polybrominated Diphenyl Ether Exposures
Chemical research in toxicology, Vol.22(1), pp.179-186
01/01/2009
DOI: 10.1021/tx8003032
PMCID: PMC3120107
PMID: 19111055
Abstract
Polybrominated diphenyl ethers (PBDEs) are flame retardants applied as coatings to many consumer products, including household items. PBDEs are released and produce airborne vapors and dusts. Inhalation of particle-phase and/or gas-phase PBDEs is therefore a major route of exposure. In an attempt to mimic realistic airborne exposures, actual uptake, and deposition of particles and vapors, we prepared and characterized particles for future animal exposure studies. To trace the particles in environmental and biological systems, we employed fluoro tagging. We synthesized, characterized, and employed three PBDE congeners, 35, 47, and 99, and five fluoro-substituted PBDEs (F-PBDEs), 17-F5', 25-F5', 28-F3', 35-F5', 47-F3, and 99-F3', for this study. The PBDE congeners were selected because they are commonly found in house dust. For that reason, we coated spherical silica particles of 3,mu m and C-18 endcapped silica as representative and inert support materials, with 20, 30, and 40% PBDEs. We determined the particle size distributions by aerodynamic particle size spectrometry and the morphology by scanning electron microscopy. The suitability of the fluoro-tagged tracers to mimic their corresponding parent PBDEs was investigated by extraction studies from spiked blood serum. Our study is of fundamental importance to the development of xenobiotic tracers for monitoring routes of human exposure to PBDEs and understanding uptake of PBDEs from particles and vapors.
Details
- Title: Subtitle
- Innovative Application of Fluoro Tagging To Trace Airborne Particulate and Gas-Phase Polybrominated Diphenyl Ether Exposures
- Creators
- Johannes Klosener - Univ Iowa, Dept Environm & Occupat Hlth, Iowa City, IA 52242 USAThomas M. Peters - University of Iowa, Occupational and Environmental HealthAndrea Adamcakova-Dodd - University of Iowa, Occupational and Environmental HealthLynn M. Teesch - University of Iowa, Core Research FacilitiesPeter S. Thorne - University of Iowa, Occupational and Environmental HealthLarry W. Robertson - University of Iowa, Occupational and Environmental HealthGregor Luthe - Univ Iowa, Dept Environm & Occupat Hlth, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Chemical research in toxicology, Vol.22(1), pp.179-186
- DOI
- 10.1021/tx8003032
- PMID
- 19111055
- PMCID
- PMC3120107
- NLM abbreviation
- Chem Res Toxicol
- ISSN
- 0893-228X
- eISSN
- 1520-5010
- Publisher
- Amer Chemical Soc
- Number of pages
- 8
- Grant note
- P30 ES05605 / University of Iowa Environmental Health Sciences Research Center P42 ES013661 / National Institute of Environmental Health Sciences (NIEHS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P42ES013661 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) Alexander von Humboldt Foundation (Bonn, Germany); Alexander von Humboldt Foundation RD-2902102 / U.S. Environmental Protection Agency; United States Environmental Protection Agency
- Language
- English
- Date published
- 01/01/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Civil and Environmental Engineering; Occupational and Environmental Health; Stead Family Department of Pediatrics; Core Research Facilities; Iowa Superfund Research Program; Medicine Administration
- Record Identifier
- 9983557696002771
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