Journal article
Insights Into the Dehydration Behavior of Thiamine Hydrochloride (vitamin B1) Hydrates: Part II
Journal of pharmaceutical sciences, Vol.99(4), pp.1882-1895
04/2010
DOI: 10.1002/jps.21968
PMID: 19824063
Abstract
Thiamine hydrochloride (THCl) can exist as an anhydrate (AH) and as a hemihydrate (HH). AH sorbs water as a function of environmental water vapor pressure to form a nonstoichiometric hydrate (NSH). NSH dehydration is initiated at ∼40°C to yield AH, an isomorphic desolvate (ID) of NSH (Chakravaty et al., 2009, J Pharm Sci). Upon heating, dehydration of HH occurs only at elevated temperatures (>120°C) and is accompanied by chemical decomposition. When heated at reduced temperature (60–90°C) and pressure (20–760 mTorr), HH was incompletely dehydrated with partial loss of long‐range lattice order. Complete dehydration of HH to AH was achieved through a solvent‐mediated transformation in ethanol. The crystal structures of NSH and HH exhibit pronounced differences in the hydrogen bonding of water. The dehydration mechanism of NSH and HH can be explained by the “continuous and unified” dehydration model.10. © 2009 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1882–1895, 2010
Details
- Title: Subtitle
- Insights Into the Dehydration Behavior of Thiamine Hydrochloride (vitamin B1) Hydrates: Part II
- Creators
- Paroma Chakravarty - Department of Pharmaceutics, University of Minnesota, Minneapolis, 9‐157 Weaver Densford Hall, 308 Harvard Street SE, Minnesota 55455Robert T Berendt - Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047Eric J Munson - Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047Victor G Young - Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455Ramprakash Govindarajan - Department of Pharmaceutics, University of Minnesota, Minneapolis, 9‐157 Weaver Densford Hall, 308 Harvard Street SE, Minnesota 55455Raj Suryanarayanan - Department of Pharmaceutics, University of Minnesota, Minneapolis, 9‐157 Weaver Densford Hall, 308 Harvard Street SE, Minnesota 55455
- Resource Type
- Journal article
- Publication Details
- Journal of pharmaceutical sciences, Vol.99(4), pp.1882-1895
- DOI
- 10.1002/jps.21968
- PMID
- 19824063
- NLM abbreviation
- J Pharm Sci
- ISSN
- 0022-3549
- eISSN
- 1520-6017
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065503102771
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