Journal article
Insights into epileptic aphasia: Intracranial recordings in a child with a left insular ganglioglioma
Epilepsy & behavior reports, Vol.28, 100715
10/2024
DOI: 10.1016/j.ebr.2024.100715
PMCID: PMC11832953
PMID: 39968245
Abstract
•Erratic behavioral performance on a dialog-based task.•Epileptic foci in auditory cortex.•Behavioral performance paralleled by physiology in auditory cortex.•Abnormalities extended into the inferior frontal gyrus and salience network.•Physiologic abnormalities mirror those in Rolandic epilepsy and epileptic aphasia.
Intracranial EEG was recorded during a dialog-based task in a 16-year-old boy with a left insular ganglioglioma, medically intractable epilepsy, epileptic foci in auditory cortex on the lateral superior temporal gyrus (STG) and language deficiencies. Performance of the task was highly erratic, characterized by rapid cycling between providing correct answers, incorrect answers and failure to respond. There was no relationship between performance and the degree of concurrent epileptic activity in auditory cortex. High gamma activity in core auditory cortex (posterior medial Heschl’s gyrus, HGPM) was markedly diminished during listening and, with two exceptions, was less than activity from 17 control subjects. The two exceptions also had seizure onset zones in perisylvian cortex. Responses during listening were of smaller amplitude than those occurring during speaking, a pattern opposite that typically seen in the left HGPM. Within HGPM, lateral STG and pars opercularis of the inferior frontal gyrus, high gamma activity while listening was greatest when questions were correctly answered and least when the subject failed to respond. Alpha activity preceding utterances was lowest in pars opercularis when the subject failed to respond. Comparisons between resting state activity in another cohort of controls and the subject were most disparate in HGPM. Alpha activity during performance of the task was greatest in the mid-anterior cingulate when the subject failed to respond, suggesting dysfunction beyond the speech network and into the salience network. Multiple abnormalities noted in this patient paralleled those seen in epileptic aphasia and Rolandic epilepsy
Details
- Title: Subtitle
- Insights into epileptic aphasia: Intracranial recordings in a child with a left insular ganglioglioma
- Creators
- Mitchell Steinschneider - University of IowaAriane E. Rhone - University of IowaPeter N. Taylor - Newcastle UniversityKirill V. Nourski - University of IowaBrian J Dlouhy - University of IowaMatthew A. Howard - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Epilepsy & behavior reports, Vol.28, 100715
- DOI
- 10.1016/j.ebr.2024.100715
- PMID
- 39968245
- PMCID
- PMC11832953
- NLM abbreviation
- Epilepsy Behav Rep
- ISSN
- 2589-9864
- eISSN
- 2589-9864
- Publisher
- Elsevier Inc
- Grant note
- National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke: K08 NS112573-01 National institute of Deafness and Other Communication Disorders: R01 DC004290 UKRI Future Leaders Fellowship: MR/T04294X/1
Funding was provided by National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke grant K08 NS112573-01 (to BJD) , National institute of Deafness and Other Communication Disorders grant R01 DC004290 (to MAH) . PNT was supported by a UKRI Future Leaders Fellowship (MR/T04294X/1) . Philanthropic support was provided by Jeffrey and Marilyn Moss, Sam Reeves, and David and Elizabeth Hoak. The authors thank Christopher Garcia and Kenji Ibayashi for assistance in data collection.
- Language
- English
- Date published
- 10/2024
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984721211502771
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