Journal article
Insights into pathologic mechanisms occurring during serious adverse events following live zoster vaccination
Journal of virology, Vol.99(2), e01816-24
02/25/2025
DOI: 10.1128/jvi.01816-24
PMCID: PMC11852805
PMID: 39818965
Abstract
An effective live zoster vaccine has been widely used around the world. Although no deaths occurred in the original large clinical trial, we analyzed 10 serious adverse events, including six deaths that have subsequently occurred in four countries. The goal is to define the viral pathogenesis of these unexpected adverse events secondary to a viremia with dissemination of the vaccine virus. We also propose a new hypothesis for acute retinal necrosis that occurs post-immunization.
Details
- Title: Subtitle
- Insights into pathologic mechanisms occurring during serious adverse events following live zoster vaccination
- Creators
- Peter G E Kennedy - University of GlasgowCharles Grose - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.99(2), e01816-24
- DOI
- 10.1128/jvi.01816-24
- PMID
- 39818965
- PMCID
- PMC11852805
- NLM abbreviation
- J Virol
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Publisher
- AMER SOC MICROBIOLOGY
- Grant note
- HHS | National Institutes of Health (NIH)
For this paper, C.G. asked Professor Kennedy to fill a role of neuroscientist. We note that the journal requests limiting the number of citations in Gem articles; therefore, the number of citations is far fewer than in a review article.
- Language
- English
- Electronic publication date
- 01/17/2025
- Date published
- 02/25/2025
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984775270002771
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