Journal article
Insights into the dehydration behavior of thiamine hydrochloride (Vitamin B1) hydrates: Part I
Journal of pharmaceutical sciences, Vol.99(2), pp.816-827
02/2010
DOI: 10.1002/jps.21876
PMID: 19623540
Abstract
Thiamine hydrochloride (Vitamin B1, THCl) can exist as a nonstoichiometric hydrate (NSH) and as a hemihydrate (HH). NSH can contain up to ∼1 molar equivalent of water and be dehydrated to an isomorphic desolvate (ID) with minimal change in lattice structure. Crystallographic and spectroscopic techniques were used to characterize the influence of structure and mobility on NSH dehydration. Dehydration was accompanied by lattice contraction, as noted by a decrease in the d-spacings. Dehydration also led to the development of surface cracks parallel to the (101―) and (102―) planes in the NSH single crystal, as observed by hot stage microscopy. Step-wise dehydration of NSH produced gradual shifts in XRPD and SSNMR peaks, indicating that NSH (with ∼1 mole water) and ID represent the two extremes of a continuum in the hydration state. Variable temperature 13C SSNMR studies showed that water molecules move rapidly at room temperature within the NSH crystal lattice, and the thiamine molecules transiently exist in distinct hydrated and dehydrated states. It is hypothesized that, despite the lack of continuous hydration channels in the NSH crystal lattice, cooperative deformation of the thiamine molecules allows a nondisruptive departure of water molecules from the lattice during dehydration. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:816–827, 2010
Details
- Title: Subtitle
- Insights into the dehydration behavior of thiamine hydrochloride (Vitamin B1) hydrates: Part I
- Creators
- Paroma Chakravarty - Department of Pharmaceutics, University of Minnesota, 9-157 Weaver Densford Hall, 308 Harvard Street SE, Minneapolis, Minnesota 55455Robert T Berendt - Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047Eric J Munson - Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047Victor G Young - Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455Ramprakash Govindarajan - Department of Pharmaceutics, University of Minnesota, 9-157 Weaver Densford Hall, 308 Harvard Street SE, Minneapolis, Minnesota 55455Raj Suryanarayanan - Department of Pharmaceutics, University of Minnesota, 9-157 Weaver Densford Hall, 308 Harvard Street SE, Minneapolis, Minnesota 55455
- Resource Type
- Journal article
- Publication Details
- Journal of pharmaceutical sciences, Vol.99(2), pp.816-827
- DOI
- 10.1002/jps.21876
- PMID
- 19623540
- NLM abbreviation
- J Pharm Sci
- ISSN
- 0022-3549
- eISSN
- 1520-6017
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 02/2010
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065314802771
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