Journal article
Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety
Bioorganic & medicinal chemistry letters, Vol.26(19), pp.4702-4704
10/01/2016
DOI: 10.1016/j.bmcl.2016.08.046
PMID: 27595422
Abstract
[Display omitted]
Compound ZJ-101, a structurally simplified analog of the marine natural product superstolide A, was previously developed in our laboratory. In the subsequent structure–activity relationship study, a new analog ZJ-109 was designed and synthesized to probe the importance of the lactone moiety of the molecule by replacing the lactone in ZJ-101 with a lactam. The biological evaluation showed that ZJ-109 is about 8–12 times less active against cancer cells in vitro than ZJ-101, suggesting that the lactone moiety of the molecule is important for its anticancer activity.
Details
- Title: Subtitle
- Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety
- Creators
- Haibo Qiu - University of IowaShan Qian - University of IowaSarah A. Head - Johns Hopkins MedicineJun O. Liu - Johns Hopkins MedicineZhendong Jin - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.26(19), pp.4702-4704
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.bmcl.2016.08.046
- PMID
- 27595422
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Grant note
- name: Office of the Vice President for Research and Economic Development; name: InnoBioPharma, award: D2015070002; DOI: 10.13039/100000002, name: National Institutes of Health, award: 1R21CA204836-01
- Language
- English
- Date published
- 10/01/2016
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984365903402771
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