Journal article
Insights into the structure–activity relationship of the anticancer compound ZJ-101: A role played by the amide moiety
Bioorganic & medicinal chemistry letters, Vol.105, 129741
06/01/2024
DOI: 10.1016/j.bmcl.2024.129741
PMCID: PMC11060512
PMID: 38599296
Abstract
ZJ-101, a structurally simplified analog of marine natural product superstolide A, was previously designed and synthesized in our laboratory. In the present study four new analogs of ZJ-101 were designed and synthesized to investigate the structure–activity relationship of the acetamide moiety of the molecule. The biological evaluation showed that the amide moiety is important for the molecule’s anticancer activity. Replacing the amide with other unctional groups such as a sulfonamide group, a carbamate group, and a urea group resulted in the decrease in anticancer activity.
Details
- Title: Subtitle
- Insights into the structure–activity relationship of the anticancer compound ZJ-101: A role played by the amide moiety
- Creators
- Haibo Qiu - University of IowaShan Qian - University of IowaSarah A. Head - Johns Hopkins MedicinePhillip R. Sanchez - Johns Hopkins MedicineJun O. Liu - Johns Hopkins MedicineZhendong Jin - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.105, 129741
- DOI
- 10.1016/j.bmcl.2024.129741
- PMID
- 38599296
- PMCID
- PMC11060512
- NLM abbreviation
- Bioorg Med Chem Lett
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: NIH
- Language
- English
- Electronic publication date
- 04/08/2024
- Date published
- 06/01/2024
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984585055902771
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