Journal article
Inspirations from tetrafibricin and related polyketides: new methods and strategies for 1,5-polyol synthesis
Natural product reports, Vol.37(9), pp.1229-1261
05/15/2020
DOI: 10.1039/c9np00070d
PMID: 32412021
Abstract
Covering: up to 2019Selective synthesis with control of remote stereogenic centers has long been a challenge in organic chemistry. In recent years the interest in this topic has been energized by isolation and synthetic studies of tetrafibricin and other natural products containing 1,5-polyols, such as amphidinol 3, marinomycins, and caylobolide. Here we discuss recent developments in 1,5-polyol synthesis, including an overview of selected bioactive natural products in this class and examples of new synthetic methodologies and strategies dedicated to remote stereocontrol in these structures. To illustrate in greater depth, we review several instructive examples of how these innovations have been applied in synthetic studies on tetrafibricin.
Details
- Title: Subtitle
- Inspirations from tetrafibricin and related polyketides: new methods and strategies for 1,5-polyol synthesis
- Creators
- Ryan M FriedrichGregory K Friestad - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA. gregory-friestad@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Natural product reports, Vol.37(9), pp.1229-1261
- DOI
- 10.1039/c9np00070d
- PMID
- 32412021
- ISSN
- 0265-0568
- eISSN
- 1460-4752
- Grant note
- DOI: 10.13039/100008893, name: University of Iowa
- Language
- English
- Date published
- 05/15/2020
- Academic Unit
- Chemistry
- Record Identifier
- 9984217451702771
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