Journal article
Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure
Biological psychiatry (1969), Vol.57(4), pp.394-398
2005
DOI: 10.1016/j.biopsych.2004.11.010
PMID: 15705355
Abstract
The insular cortex is a limbic integration region engaged in emotional and cognitive functions. Previously, we found that neuroleptic-naïve subjects had abnormally small insular volumes compared with control subjects, with volume directly related to severity of psychotic symptoms.
To further investigate insular cortex abnormalities and their functional correlates, we measured insular gray matter volume and cortical surface size, using magnetic resonance images among 30 patients with schizophrenia and a matched control group. The sample was designed to represent a variety of phenomenologic profiles to provide sufficient variance in multiple measures, including severity of illness and exposure to neuroleptics (typical only).
There were no significant differences in morphology between patients and control subjects; however, among patients, psychotic symptoms were inversely correlated with insular volume, replicating our previous finding in neuroleptic-naïve subjects. Neuroleptic exposure had a specific effect on insular morphology: increasing drug exposure (measured in dose-years) correlated with larger insular volume.
This effect of neuroleptic exposure might account for the lack of difference in structural measures in this more chronic sample, whereas the initial study on neuroleptic-naïve subjects showed group differences. Further research is needed to investigate the potential relationship between changes in insula volume from neuroleptic exposure and clinical outcome.
Details
- Title: Subtitle
- Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure
- Creators
- Marcus Pressler - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IowaPeg Nopoulos - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IowaBeng-Choon Ho - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IowaNancy C Andreasen - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.57(4), pp.394-398
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.biopsych.2004.11.010
- PMID
- 15705355
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Language
- English
- Date published
- 2005
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984003455702771
Metrics
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