Journal article
Insulin-Like Growth Factor Axis and Gestational Diabetes Mellitus: A Longitudinal Study in a Multiracial Cohort
Diabetes (New York, N.Y.), Vol.65(11), pp.3495-3504
11/2016
DOI: 10.2337/db16-0514
PMCID: PMC5079637
PMID: 27468747
Abstract
The insulin-like growth factor (IGF) axis may be implicated in glucose homeostasis, but its longitudinal profile across gestation in relation to the development of gestational diabetes mellitus (GDM) is largely unknown. We prospectively investigated IGF axis biomarkers in early-to-midpregnancy in relation to subsequent GDM risk in a case-control study of 107 case subjects with GDM and 214 control subjects without GDM, with blood sample collection at gestational weeks 10-14, 15-26, 23-31, and 33-39. Conditional logistic regression was used, adjusting for major risk factors including prepregnancy BMI. Plasma IGF-I and IGF binding protein 3 (IGFBP-3) concentrations and molar ratio of IGF-I to IGFBP-3 increased, whereas IGFBP-2 decreased throughout pregnancy. At gestational weeks 10-14, both IGF-I and IGF-I/IGFBP-3 were positively associated with GDM risk; adjusted odds ratio (OR) comparing the highest versus lowest quartile (OR
) was 2.93 (95% CI 1.18, 7.30) for IGF-I and 3.31 (1.10, 9.98) for IGF-I/IGFBP-3. In contrast, higher IGFBP-2 levels were related to a substantially lower risk of GDM (OR
0.04 [0.01, 0.06]). Similar results were observed at gestational weeks 15-26. In sum, the IGF axis, IGFBP-2 in particular, may be implicated in the pathogenesis of GDM, with significant associations and incremental predictive value detected as early as gestational weeks 10-14, ∼10-18 weeks earlier before GDM is typically screened for.
Details
- Title: Subtitle
- Insulin-Like Growth Factor Axis and Gestational Diabetes Mellitus: A Longitudinal Study in a Multiracial Cohort
- Creators
- Yeyi Zhu - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MDPauline Mendola - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MDPaul S Albert - Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MDWei Bao - Department of Epidemiology, University of Iowa, Iowa City, IAStefanie N Hinkle - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MDMichael Y Tsai - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MNCuilin Zhang - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD zhangcu@mail.nih.gov
- Resource Type
- Journal article
- Publication Details
- Diabetes (New York, N.Y.), Vol.65(11), pp.3495-3504
- Publisher
- United States
- DOI
- 10.2337/db16-0514
- PMID
- 27468747
- PMCID
- PMC5079637
- ISSN
- 0012-1797
- eISSN
- 1939-327X
- Grant note
- HHSN275200800012C / NICHD NIH HHS HHSN275200800013C / NICHD NIH HHS HHSN275200800014C / NICHD NIH HHS HHSN275200800028C / NICHD NIH HHS HHSN275201000009C / NICHD NIH HHS HHSN275201000001G / NICHD NIH HHS HHSN275201000001Z / NICHD NIH HHS HHSN275200800002I / NICHD NIH HHS HHSN275200800002C / NICHD NIH HHS HHSN275200800003C / NICHD NIH HHS HHSN275200800003I / NICHD NIH HHS
- Language
- English
- Date published
- 11/2016
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983996056002771
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