Journal article
Insulin-Like Growth Factor I Accelerates Functional Recovery from Achilles Tendon Injury in a Rat Model
The American journal of sports medicine, Vol.27(3), pp.363-369
05/1999
DOI: 10.1177/03635465990270031701
PMID: 10352775
Abstract
We studied the effects of insulin-like growth factor I on Achilles tendon healing
in a rat model. Rats were randomized into groups of six each: sham surgery,
transection alone, and transection plus growth factor. Postoperatively, rats
treated with growth factor had a significantly smaller maximum functional
deficit and a decreased time to functional recovery than rats in the untreated
groups. Biomechanical testing revealed no significant differences in the
measured parameters between the treated and the untreated groups after
transection. To study the mechanism of action, six additional animals received
an Achilles tendon injection of the inflammatory agent carrageenan alone and six
received carrageenan plus growth factor. Rats treated with growth factor did not
show the inflammation-induced functional deficit experienced by the control
rats. Spectrometric myeloperoxidase assays on the remaining eight rats after
Achilles tendon transection demonstrated no significant difference between the
untreated and the growth factor-treated groups, indicating a mechanism other
than neutrophil recruitment by which the growth factor limits inflammation.
Histologic studies were performed on carrageenan-injected rats at postinjection
day 2 and on surgically treated rats at postoperative day 15. No gross
histologic differences were seen between untreated and growth factor-treated
groups. This study demonstrated that via a possible antiinflammatory mechanism,
insulin-like growth factor I reduces maximum functional deficit and accelerates
recovery after Achilles tendon injury.
Details
- Title: Subtitle
- Insulin-Like Growth Factor I Accelerates Functional Recovery from Achilles Tendon Injury in a Rat Model
- Creators
- Christopher A Kurtz - Department of Orthopaedic Surgery, Allegheny General Hospital, Allegheny University of the Health Sciences, Pittsburgh, PennsylvaniaThomas G Loebig - Department of Orthopaedic Surgery, Allegheny General Hospital, Allegheny University of the Health Sciences, Pittsburgh, PennsylvaniaDonald D Anderson - Biomechanics Laboratory, Minneapolis Sports Medicine Center, Minneapolis, MinnesotaPatrick J DeMeo - Department of Orthopaedic Surgery, Allegheny General Hospital, Allegheny University of the Health Sciences, Pittsburgh, PennsylvaniaPhil G Campbell - Department of Orthopaedic Surgery, Allegheny General Hospital, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania, Institute for Complex Engineered Systems, Carnegie Mellon University, 2218 Hamburg Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890
- Resource Type
- Journal article
- Publication Details
- The American journal of sports medicine, Vol.27(3), pp.363-369
- Publisher
- SAGE Publications; Los Angeles, CA
- DOI
- 10.1177/03635465990270031701
- PMID
- 10352775
- ISSN
- 0363-5465
- eISSN
- 1552-3365
- Language
- English
- Date published
- 05/1999
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Industrial and Systems Engineering
- Record Identifier
- 9984040278202771
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