Journal article
Insulin Regulation of Myocardial Autophagy
Circulation journal : official journal of the Japanese Circulation Society, Vol.78(11), pp.2569-2576
2014
DOI: 10.1253/circj.CJ-14-1080
PMCID: PMC5609463
PMID: 25327953
Abstract
Autophagy is a conserved cellular process that plays an important role in cardiovascular homeostasis. Basal levels of autophagy are required for the maintenance of organellar quality control. Autophagy is dynamically regulated in the heart in the fasting to re-feeding transition. Insulin signaling plays an important role in the regulation of myocardial fuel metabolism, mitochondrial function and cellular growth. Recent studies have suggested an important role for insulin signaling in the regulation of myocardial autophagy. This dynamic regulation of autophagy induction during fasting may contribute to organellar homeostasis and if perturbed under conditions of hyperinsulinemia could contribute to accelerated cardiac aging. (Circ J 2014; 78: 2569–2576)
Details
- Title: Subtitle
- Insulin Regulation of Myocardial Autophagy
- Creators
- Christian Riehle - Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of IowaE. Dale Abel - Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Circulation journal : official journal of the Japanese Circulation Society, Vol.78(11), pp.2569-2576
- Publisher
- 一般社団法人 日本循環器学会
- DOI
- 10.1253/circj.CJ-14-1080
- PMID
- 25327953
- PMCID
- PMC5609463
- ISSN
- 1346-9843
- eISSN
- 1347-4820
- Language
- English
- Date published
- 2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024555302771
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