Journal article
Insulin Regulation of Proteostasis and Clinical Implications
Cell metabolism, Vol.26(2), pp.310-323
08/01/2017
DOI: 10.1016/j.cmet.2017.06.010
PMCID: PMC8020859
PMID: 28712655
Abstract
Maintenance and modification of the cellular proteome are at the core of normal cellular physiology. Although insulin is well known for its control of glucose homeostasis, its critical role in maintaining proteome homeostasis (proteostasis) is less appreciated. Insulin signaling regulates protein synthesis and degradation as well as posttranslational modifications at the tissue level and coordinates proteostasis at the organism level. Here, we review regulation of proteostasis by insulin in postabsorptive, postprandial, and diabetic states. We present the effects of insulin on amino acid flux in skeletal muscle and splanchnic tissues, the regulation of protein quality control, and turnover of mitochondrial protein pools in humans. We also review the current evidence for the mechanistic control of proteostasis by insulin and insulin-like growth factor 1 receptors based on preclinical studies. Finally, we discuss irreversible posttranslational modifications of the proteome in diabetes and how future investigations will provide new insights into mechanisms of diabetic complications.
Details
- Title: Subtitle
- Insulin Regulation of Proteostasis and Clinical Implications
- Creators
- Haleigh A. James - Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First Street SW Rochester, MN, 55905, USA.Brian T. O'Neill - Univ Iowa, Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Div Endocrinol & Metab, Iowa City, IA 52242 USAK. Sreekumaran Nair - Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First Street SW Rochester, MN, 55905, USA.
- Resource Type
- Journal article
- Publication Details
- Cell metabolism, Vol.26(2), pp.310-323
- DOI
- 10.1016/j.cmet.2017.06.010
- PMID
- 28712655
- PMCID
- PMC8020859
- NLM abbreviation
- Cell Metab
- ISSN
- 1550-4131
- eISSN
- 1932-7420
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- K08DK100543 / National Institute of Diabetes and Digestive and Kidney Diseases of the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K08DK100543 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Mayo Clinic RO1 DK 41973; AG 09531; U24DK100469 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 08/01/2017
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359841302771
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