Journal article
Insulin Resistance: Metabolic mechanisms and consequences in the heart
Arteriosclerosis, thrombosis, and vascular biology, Vol.32(9), pp.2068-2076
09/2012
DOI: 10.1161/ATVBAHA.111.241984
PMCID: PMC3646067
PMID: 22895668
Abstract
Insulin resistance is a characteristic feature of obesity and Type 2 diabetes and impacts the heart in various ways. Impaired insulin-mediated glucose uptake is a uniformly observed characteristic of the heart in these states, although changes in upstream kinase signaling are variable and dependent on the severity and duration of the associated obesity or diabetes. The understanding of the physiological and pathophysiological role of insulin resistance in the heart is evolving. To maintain its high energy demands, the heart is capable of utilizing many metabolic substrates. Although, insulin signaling may directly regulate cardiac metabolism, its main role is likely the regulation of substrate delivery from the periphery to the heart. In addition to promoting glucose uptake, insulin regulates long chain fatty acid uptake, protein synthesis, and vascular function in the normal cardiovascular system. Recent advances in understanding the role of metabolic, signaling, and inflammatory pathways in obesity have provided opportunities to better understand the pathophysiology of insulin resistance in the heart. This review will summarize our current understanding of metabolic mechanisms for and consequences of insulin resistance in the heart and discuss potential new areas for investigating novel mechanisms that contribute to insulin resistance in the heart.
Details
- Title: Subtitle
- Insulin Resistance: Metabolic mechanisms and consequences in the heart
- Creators
- E. Dale Abel - Division of Endocrinology, Metabolism and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UtahKaren M O'Shea - Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, NY 10016Ravichandran Ramasamy - Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, NY 10016
- Resource Type
- Journal article
- Publication Details
- Arteriosclerosis, thrombosis, and vascular biology, Vol.32(9), pp.2068-2076
- DOI
- 10.1161/ATVBAHA.111.241984
- PMID
- 22895668
- PMCID
- PMC3646067
- ISSN
- 1079-5642
- eISSN
- 1524-4636
- Grant note
- R01 HL073167 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL070070 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 DK092065 || DK / National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK P01 HL060901 || HL / National Heart, Lung, and Blood Institute : NHLBI
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024539202771
Metrics
10 Record Views