Journal article
Insulin-resistance and benign prostatic hyperplasia: The connection
European journal of pharmacology, Vol.641(2-3), pp.75-81
09/01/2010
DOI: 10.1016/j.ejphar.2010.05.042
PMID: 20553919
Abstract
Benign prostatic hyperplasia (BPH) is a highly prevalent disease in the aged men population characterized by augmented cell proliferation and contractility of the prostate gland. Prior studies have demonstrated the relationship between BPH and insulin-resistance syndrome. During insulin-resistance, hyperinsulinemia develops to combat the decreased responsiveness of the body towards insulin. Although, the compensatory hyperinsulinemia prevents development of fasting hyperglycemia in insulin-resistant individuals, the increased level of circulating insulin directly and/or indirectly affects different molecular signaling and can promote prostatic growth. Insulin-resistance syndrome includes group of disorders, such as obesity, dyslipidemia, sympathetic overactivity, hyperinsulinemia and each individually reported as risk factor for the development of BPH. The present review describes the inter-relationships between different insulinresistance associated factors and their possible involvement in the pathogenesis of BPH. (C) 2010 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Insulin-resistance and benign prostatic hyperplasia: The connection
- Creators
- Ajit Vikram - National Institute of Pharmaceutical Education and ResearchGopabandhu Jena - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Mohali, Punjab-160 062, IndiaPoduri Ramarao - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Mohali, Punjab-160 062, India
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.641(2-3), pp.75-81
- Publisher
- Elsevier
- DOI
- 10.1016/j.ejphar.2010.05.042
- PMID
- 20553919
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Number of pages
- 7
- Grant note
- National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Mohali, Punjab, India
- Language
- English
- Date published
- 09/01/2010
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984359940302771
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