Journal article
Insulin signaling in heart muscle: lessons from genetically engineered mouse models
Current hypertension reports, Vol.6(6), pp.416-423
12/2004
DOI: 10.1007/s11906-004-0034-4
PMID: 15527684
Abstract
The heart is an insulin-responsive organ, and disorders of insulin action, such as diabetes and obesity, can have profound effects on cardiac performance. Insulin signaling influences numerous functions within the heart, such as metabolic substrate preference, cell size, and the response of the heart to ischemia and hypertrophy. Because the systemic consequences of altered insulin action can have significant but indirect effects on the heart, the generation of mice with altered expression of insulin receptors and key components of the insulin-signal transduction pathways in cardiomyocytes have led to interesting and occasionally surprising new insights into the regulation of cardiac biology by insulin.
Details
- Title: Subtitle
- Insulin signaling in heart muscle: lessons from genetically engineered mouse models
- Creators
- E Dale Abel - Division of Endocrinology, Metabolism and Diabetes, University of Utah, 15 North 2030 East, Building #533, Room 3410B, Salt Lake City, UT 84112, USA. dale.abel@hmbg.utah.edu
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.6(6), pp.416-423
- Publisher
- United States
- DOI
- 10.1007/s11906-004-0034-4
- PMID
- 15527684
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Language
- English
- Date published
- 12/2004
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984025254002771
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