Journal article
Insulin stimulation of GLUT-4 translocation: a model for regulated recycling
Trends in Cell Biology, Vol.4(4), pp.120-126
1994
DOI: 10.1016/0962-8924(94)90066-3
PMID: 14731734
Abstract
Insulin stimulates glucose transport in muscle and fat cells by causing the redistribution of a facilitative glucose transporter, GLUT-4, from an intracellular compartment to the cell surface. But what is this intracellular GLUT-4 compartment? It may be a specialized compartment, perhaps analogous to synaptic vesicles, or may simply be part of the endosomal system. Other constituents of this compartment might be regulators of GLUT-4 movement to the cell surface, and their identification should make it possible to find the link between the insulin signal transduction pathway and GLUT-4 translocation.
Details
- Title: Subtitle
- Insulin stimulation of GLUT-4 translocation: a model for regulated recycling
- Creators
- David E. James - University of QueenslandRobert C. Piper - University of OregonJan W. Slot - Utrecht University
- Resource Type
- Journal article
- Publication Details
- Trends in Cell Biology, Vol.4(4), pp.120-126
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/0962-8924(94)90066-3
- PMID
- 14731734
- ISSN
- 0962-8924
- eISSN
- 1879-3088
- Language
- English
- Date published
- 1994
- Academic Unit
- Molecular Physiology and Biophysics; Medicine Administration; Internal Medicine
- Record Identifier
- 9984297604502771
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