Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

Seungyoun Jung; Olga Goloubeva; Nola Hylton; Catherine Klifa; Erin LeBlanc; John Shepherd; Linda Snetselaar; Linda Van Horn; Joanne F Dorgan

doi:10.1007/s10552-018-1040-1

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Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

Journal article

Peer reviewed

Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

Seungyoun Jung, Olga Goloubeva, Nola Hylton, Catherine Klifa, Erin LeBlanc, John Shepherd, Linda Snetselaar, Linda Van Horn and Joanne F Dorgan

Cancer causes & control, Vol.29(7), pp.631-642

07/2018

DOI: 10.1007/s10552-018-1040-1

PMCID: PMC7365352

PMID: 29802491

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Abstract

Carbohydrate intake increases postprandial insulin secretion and may affect breast density, a strong risk factor for breast cancer, early in life. We examined associations of adolescent and early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars with breast density among 182 young women. Diet was assessed using three 24-h recalls at each of five Dietary Intervention Study in Children (DISC) clinic visits when participants were age 10-19 years and at the DISC06 Follow-Up Study clinic visit when participants were age 25-29 years. Associations between energy-adjusted carbohydrates and MRI-measured percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) at 25-29 years were quantified using multivariable-adjusted mixed-effects linear models. Adolescent sucrose intakes and premenarcheal total carbohydrates intakes were modestly associated with higher %DBV (mean %DBV , 16.6 vs 23.5% for sucrose; and 17.2 vs 22.3% for premenarcheal total carbohydrates, all P ≤ 0.02), but not with ADBV. However, adolescent intakes of fiber and fructose were not associated with %DBV and ADBV. Early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars were not associated with %DBV and ADBV. Insulinemic carbohydrate diet during puberty may be associated with adulthood breast density, but our findings need replication in larger studies. Clinical Trials Registration ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

Dietary Carbohydrates - administration & dosage

Follow-Up Studies

Glycemic Index

Humans

Risk Factors

Breast Neoplasms - etiology

Magnetic Resonance Imaging

Diet

Adolescent

Adult

Dietary Fiber

Female

Glycemic Load

Breast Density - physiology

Child

Details

Title: Subtitle: Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women
Creators: Seungyoun Jung - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall 102E, Baltimore, MD, 21201, USA
Olga Goloubeva - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall 102E, Baltimore, MD, 21201, USA
Nola Hylton - Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
Catherine Klifa - Dangeard Group, Luynes, France
Erin LeBlanc - Kaiser Permanente Center for Health Research, Portland, OR, USA
John Shepherd - University of Hawaii Cancer Center, Honolulu, HI, USA
Linda Snetselaar - Department of Epidemiology, University of Iowa, Iowa City, IA, USA
Linda Van Horn - Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Joanne F Dorgan - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall 102E, Baltimore, MD, 21201, USA. jdorgan@som.umaryland.edu
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.29(7), pp.631-642
DOI: 10.1007/s10552-018-1040-1
PMID: 29802491
PMCID: PMC7365352
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Publisher: Netherlands
Grant note: R01 CA116182 / NCI NIH HHS R01 CA104670 / NCI NIH HHS U01 CA225427 / NCI NIH HHS P30 CA086862 / NCI NIH HHS R03 CA167764 / NCI NIH HHS
Language: English
Date published: 07/2018
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983996062502771

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