Journal article
Integrase-defective lentiviral vectors: progress and applications
Gene therapy, Vol.17(2), pp.150-157
2010
DOI: 10.1038/gt.2009.135
PMID: 19847206
Abstract
Lentiviral vectors (LVs) offer the advantages of a large packaging capacity, broad cell tropism or specific cell-type targeting through pseudotyping, and long-term expression from integrated gene cassettes. However, transgene integration carries a risk of disrupting gene expression through insertional mutagenesis and may not be required for all applications. A non-integrating LV may be beneficial in cases in which transient gene expression is desired. Several recent publications outline the development and initial biological characterization of such vectors. Here, we discuss the potential applications and new directions for the development of integration-defective LVs.
Details
- Title: Subtitle
- Integrase-defective lentiviral vectors: progress and applications
- Creators
- M. B BANASIK - Department of Pediatrics, Program in Gene Therapy, Carver College of Medicine, The University of Iowa, Iowa City, IA, United StatesP. B MCCRAY - Department of Pediatrics, Program in Gene Therapy, Carver College of Medicine, The University of Iowa, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- Gene therapy, Vol.17(2), pp.150-157
- DOI
- 10.1038/gt.2009.135
- PMID
- 19847206
- NLM abbreviation
- Gene Ther
- ISSN
- 0969-7128
- eISSN
- 1476-5462
- Publisher
- Nature Publishing Group
- Language
- English
- Date published
- 2010
- Academic Unit
- Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984093231402771
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