Journal article
Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types
Cell reports (Cambridge), Vol.23(1), pp.213-226.e3
04/03/2018
DOI: 10.1016/j.celrep.2018.03.047
PMCID: PMC5916807
PMID: 29617661
Abstract
Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer Genome Atlas, we perform comprehensive molecular characterization of 929 ubiquitin-related genes and 95 deubiquitinase genes. Among them, we systematically identify top somatic driver candidates, including mutated FBXW7 with cancer-type-specific patterns and amplified MDM2 showing a mutually exclusive pattern with BRAF mutations. Ubiquitin pathway genes tend to be upregulated in cancer mediated by diverse mechanisms. By integrating pan-cancer multiomic data, we identify a group of tumor samples that exhibit worse prognosis. These samples are consistently associated with the upregulation of cell-cycle and DNA repair pathways, characterized by mutated TP53, MYC/TERT amplification, and APC/PTEN deletion. Our analysis highlights the importance of the ubiquitin pathway in cancer development and lays a foundation for developing relevant therapeutic strategies.
Details
- Title: Subtitle
- Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types
- Creators
- Zhongqi Ge - The University of Texas MD Anderson Cancer CenterJake S Leighton - The University of Texas at AustinYumeng Wang - Baylor College of MedicineXinxin Peng - The University of Texas MD Anderson Cancer CenterZhongyuan Chen - Rice UniversityHu Chen - Baylor College of MedicineYutong Sun - The University of Texas MD Anderson Cancer CenterFan Yao - The University of Texas MD Anderson Cancer CenterJun Li - The University of Texas MD Anderson Cancer CenterHuiwen Zhang - The University of Texas Health Science Center at HoustonJianfang LiuCraig D Shriver - Walter Reed National Military Medical CenterHai HuHelen Piwnica-Worms - The University of Texas MD Anderson Cancer CenterLi Ma - The University of Texas MD Anderson Cancer CenterHan Liang - The University of Texas MD Anderson Cancer Center
- Contributors
- Cancer Genome Atlas Research Network (Contributor)Deqin Ma (Contributor) - University of Iowa, PathologyMohammed M Milhem (Contributor) - University of Iowa, Internal MedicineAaron D Bossler (Contributor) - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.23(1), pp.213-226.e3
- DOI
- 10.1016/j.celrep.2018.03.047
- PMID
- 29617661
- PMCID
- PMC5916807
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Grant note
- U24 CA143843 / NCI NIH HHS R01 CA166051 / NCI NIH HHS U24 CA210957 / NCI NIH HHS U24 CA209851 / NCI NIH HHS U54 HG003079 / NHGRI NIH HHS U24 CA143883 / NCI NIH HHS U24 CA210990 / NCI NIH HHS U24 CA143799 / NCI NIH HHS R01 CA181029 / NCI NIH HHS R50 CA221675 / NCI NIH HHS U24 CA143867 / NCI NIH HHS U24 CA143858 / NCI NIH HHS U24 CA143882 / NCI NIH HHS U54 HG003067 / NHGRI NIH HHS U24 CA143845 / NCI NIH HHS U24 CA143835 / NCI NIH HHS U24 CA143840 / NCI NIH HHS U54 HG003273 / NHGRI NIH HHS U24 CA144025 / NCI NIH HHS U24 CA210950 / NCI NIH HHS U24 CA143866 / NCI NIH HHS U24 CA210949 / NCI NIH HHS R01 CA175486 / NCI NIH HHS R01 CA163722 / NCI NIH HHS U24 CA143848 / NCI NIH HHS
- Language
- English
- Date published
- 04/03/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
- Record Identifier
- 9984183983702771
Metrics
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