Integrating the stress response: lessons for neurodegenerative diseases from C. elegans

Veena Prahlad; Richard I Morimoto

doi:10.1016/j.tcb.2008.11.002

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Integrating the stress response: lessons for neurodegenerative diseases from C. elegans

Journal article

Open access

Peer reviewed

Integrating the stress response: lessons for neurodegenerative diseases from C. elegans

Veena Prahlad and Richard I Morimoto

Trends in cell biology, Vol.19(2), pp.52-61

02/2009

DOI: 10.1016/j.tcb.2008.11.002

PMCID: PMC4843516

PMID: 19112021

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Abstract

All cells possess surveillance and homeostatic mechanisms to adjust protein biogenesis to the demands of growth, differentiation, ageing and environmental stress. However, under certain circumstances, these mechanisms fail to adequately respond to proteotoxic imbalances and result in the accumulation of misfolded proteins. In humans, this can lead to neurodegeneration and other protein conformational diseases. To protect itself, the cell employs highly conserved stress responses and chaperone networks to maintain protein-folding homeostasis (proteostasis). Although the regulation of stress responses, such as the heat-shock response, and of proteostasis have been widely considered to be cell autonomous, recent studies using Caenorhabditis elegans have shown that these processes are regulated by neuronal signaling and endocrine pathways and integrated into other functions of the organism. The hierarchical control of the cellular proteostasis machinery affords insight into the organization of stress regulatory networks in multicellular organisms and offers novel targets for the treatment of human protein conformational diseases.

Stress, Physiological - physiology

Caenorhabditis elegans - physiology

Animals

Neurodegenerative Diseases - physiopathology

Humans

Neurosecretory Systems - physiology

Endoplasmic Reticulum - physiology

Signal Transduction - physiology

Caenorhabditis elegans Proteins - physiology

Heat-Shock Response - physiology

Protein Folding

Disease Models, Animal

Details

Title: Subtitle: Integrating the stress response: lessons for neurodegenerative diseases from C. elegans
Creators: Veena Prahlad - Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
Richard I Morimoto
Resource Type: Journal article
Publication Details: Trends in cell biology, Vol.19(2), pp.52-61
DOI: 10.1016/j.tcb.2008.11.002
PMID: 19112021
PMCID: PMC4843516
NLM abbreviation: Trends Cell Biol
ISSN: 0962-8924
eISSN: 1879-3088
Publisher: England
Grant note: R01 AG026647 / NIA NIH HHS R01 GM038109 / NIGMS NIH HHS R37 GM038109 / NIGMS NIH HHS
Language: English
Date published: 02/2009
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9983991982102771

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