Integration and dosimetric validation of a dynamic collimation system for pencil beam scanning proton therapy

Nicholas P Nelson; Wesley S Culberson; Daniel E Hyer; Theodore J Geoghegan; Kaustubh A Patwardhan; Blake R Smith; Ryan T Flynn; Alonso N Gutiérrez; Thibault Boland; Patrick M Hill

doi:10.1088/2057-1976/ad02ff

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Integration and dosimetric validation of a dynamic collimation system for pencil beam scanning proton therapy

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Integration and dosimetric validation of a dynamic collimation system for pencil beam scanning proton therapy

Nicholas P Nelson, Wesley S Culberson, Daniel E Hyer, Theodore J Geoghegan, Kaustubh A Patwardhan, Blake R Smith, Ryan T Flynn, Alonso N Gutiérrez, Thibault Boland and Patrick M Hill

Biomedical physics & engineering express, Vol.9(6), 065024

11/2023

DOI: 10.1088/2057-1976/ad02ff

PMCID: PMC11128250

PMID: 37832529

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Abstract

OBJECTIVE To integrate a Dynamic Collimation System (DCS) into a pencil beam scanning proton therapy (PBS-PT) system to validate its dosimetric impact. Approach: Uncollimated and collimated treatment fields were developed for clinically relevant targets using an in-house treatment plan optimizer and an experimentally validated Monte Carlo model of the DCS and IBA dedicated nozzle (DN) system. The dose reduction induced by the DCS was quantified by calculating the mean dose in 10- and 30-mm two-dimensional rind regions surrounding the target. A select number of plans were then used to experimentally validate the mechanical integration of the DCS and beam scanning controller system through measurements with the MatriXX-PT ionization chamber array and EBT3 film. Absolute doses were verified at the central axis at various depths using the IBA MatriXX-PT and PPC05 ionization chamber. Main results: Simulations demonstrated a maximum mean dose reduction of 12% for the 10 mm rind region and 45% for the 30 mm rind region when utilizing the DCS. Excellent agreement was observed between Monte Carlo simulations, EBT3 film, and MatriXX-PT measurements, with two-dimensional gamma pass rates exceeding 94.9% for all tested plans at the 3%/2 mm criterion. Absolute central axis doses showed an average verification difference of 1.4% between Monte Carlo and MatriXX-PT/PPC05 measurements. Significance: We have successfully dosimetrically validated the delivery of dynamically collimated PBS-PT for clinically relevant delivery patterns and dose distributions with the DCS. Monte Carlo simulations were employed to assess dose reductions and treatment planning considerations associated with the DCS.&#xD.

Details

Title: Subtitle: Integration and dosimetric validation of a dynamic collimation system for pencil beam scanning proton therapy
Creators: Nicholas P Nelson - University of Wisconsin–Madison
Wesley S Culberson - University of Wisconsin–Madison
Daniel E Hyer - University of Iowa
Theodore J Geoghegan - University of Iowa
Kaustubh A Patwardhan - University of Iowa
Blake R Smith - University of Iowa
Ryan T Flynn - University of Iowa
Alonso N Gutiérrez - Baptist Health South Florida
Thibault Boland - Ion Beam Applications (Belgium)
Patrick M Hill - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Biomedical physics & engineering express, Vol.9(6), 065024
DOI: 10.1088/2057-1976/ad02ff
PMID: 37832529
PMCID: PMC11128250
NLM abbreviation: Biomed Phys Eng Express
ISSN: 2057-1976
eISSN: 2057-1976
Grant note: DOI: 10.13039/100007316, name: Division of Cancer Prevention, National Cancer Institute, award: R37CA226518
Language: English
Electronic publication date: 10/13/2023
Date published: 11/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
Record Identifier: 9984482558402771

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