Journal article
Integration of diverse information in working memory within the frontal lobe
Nature neuroscience, Vol.3(1), pp.85-90
01/2000
DOI: 10.1038/71156
PMID: 10607400
Abstract
Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of verbal and spatial information, activation of prefrontal cortex was greater for maintaining integrated rather than unintegrated representations. Posterior brain regions showed the opposite pattern. These results demonstrate frontal-lobe specialization in maintaining working-memory representations that integrate verbal and spatial information. The role of prefrontal cortex in integrating multiple forms of information in working memory may underlie its unique contribution to high-level cognition that demands flexible mental representations.
Details
- Title: Subtitle
- Integration of diverse information in working memory within the frontal lobe
- Creators
- V Prabhakaran - Program in Neurosciences, Jordan Hall, Bldg. 420, Stanford University, Stanford, California 94305, USA. vivekpr@leland.stanford.eduK NarayananZ ZhaoJ D Gabrieli
- Resource Type
- Journal article
- Publication Details
- Nature neuroscience, Vol.3(1), pp.85-90
- Publisher
- United States
- DOI
- 10.1038/71156
- PMID
- 10607400
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- Language
- English
- Date published
- 01/2000
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020887402771
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